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Glossary Stem Cell Loss

reduction of regenerative cells impairing tissue repair and growth

Stem cell loss refers to the reduction or depletion of stem cells in a particular tissue or organ. Stem cells are crucial for regenerating and repairing tissues, so their loss can lead to impaired healing and tissue degeneration. In the context of hair, stem cell loss in hair follicles can contribute to conditions like alopecia, where hair growth is significantly reduced or halted.

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Research

5 / 1000+ results

research Deletion of the Developmentally Essential Gene ATR in Adult Mice Leads to Age-Related Phenotypes and Stem Cell Loss

688 citations , June 2007 in “Cell Stem Cell”

This study found that deleting the ATR gene in adult mice led to rapid onset of age-related traits such as hair graying and osteoporosis through reduced regenerative capacity.

Adipose-Derived Stem Cell-Based Therapies for Male/Female Pattern Hair Loss

research Adipose derived stem cell based therapies or male/female pattern hair loss

1 citations , January 2016 in “Journal of stem cell research and medicine”

Fat-derived stem cell therapies can potentially increase hair growth and thickness in people with hair loss.

research Adipose derived stem cell based therapies or male/female pattern hair loss

1 citations , January 2016 in “Journal of stem cell research and medicine”

Fat-derived stem cell therapies can potentially increase hair growth and thickness in people with hair loss.

Clinical and Histopathological Features of Hair Loss in 17 Japanese Patients With Hematologic Disorders Following Hematopoietic Stem Cell Transplantation and Chemotherapy: A Case Series

research Clinical and Histopathological Features of Hair Loss in 17 Japanese Patients With Hematologic Disorders Following Hematopoietic Stem Cell Transplantation and Chemotherapy: A Case Series.

September 2025 in “PubMed”

In this study, researchers observed diffuse hair loss in Japanese patients post-hematopoietic stem cell transplantation and chemotherapy, with treatments targeting hair follicle miniaturization, like topical minoxidil, improving hair volume in about 52.9% of cases.

research A preliminary result of adipose derived stem cell treatment for female pattern hair loss

April 2021 in “Journal of Cosmetic Dermatology”

Stem cell treatment improved hair density in female hair loss patient.

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Community Join

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community Stem cell-grown hair could help those with hair loss

12 upvotes 11 years ago

Stem cell-grown hair could potentially help those with hair loss. Treatments discussed include Minoxidil, finasteride, and RU58841.

community 42F: Has anyone tried stem-cell injections for hair loss? How was that?

in Female 4 upvotes 4 weeks ago

A 42-year-old woman is exploring stem-cell and exosome treatments for hair loss, seeking personal experiences from others. Responses suggest these treatments have mediocre results, with minoxidil being recommended as more effective for women.

community Looking for stem cell regrowth options combatting hair loss - German startup seems interesting??

8 upvotes 3 years ago

A German startup, Mane Biotech, developed a head wearable device to reactivate hair follicle stem cells, sparking skepticism among users. Some users suspect it might be a scam, while others are interested in more information from the company's newsletter.

community A cure for baldness? Stem cell researchers race to regenerate follicles from hair resistant to loss

23 upvotes 12 years ago

Researchers are working on regenerating hair follicles using stem cells, but a cure for baldness is still years away. Current treatments mentioned include Minoxidil, finasteride, and RU58841.

community Can anyone share experience with stem cell injections for hairloss?

in Chat 4 upvotes 2 years ago

Stem cell injections for hair loss are being discussed, with concerns about their effectiveness and high cost. The user is considering this treatment before opting for a hair transplant.

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Learn

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learn Stem Cell Factor

Can stem cell factor be combined with other topical hair loss solutions? No published human trial has tested topical stem cell factor alongside minoxidil or other established treatments, so neither the safety nor the benefit of the combination has been established. Community users report layering these products, but that is anecdote rather than clinical evidence.
What is stem cell factor and why is it used in hair growth treatments? Stem cell factor promotes hair growth by signaling cell survival and division.

learn Hair Transplant

Can a hair transplant be combined with other treatments? Clinics commonly say a transplant is combined with other treatments, most often minoxidil, finasteride or PRP, but the evidence behind each add-on differs. Some of the add-ons offered, such as stem-cell or exosome products, are not approved treatments for hair loss.
Can PRP be combined with a hair transplant? Providers routinely offer PRP alongside a hair transplant and most say it speeds healing and supports graft survival; the published human studies are small and mixed, so the size of any benefit is unsettled.
Is a hair transplant permanent? Transplanted hair is generally permanent but requires ongoing care to maintain results.

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn PP405

mitochondrial pyruvate carrier (MPC) inhibitor by Pelage in early trials

learn Stemoxydine

chemical from L'Oreal that encourages hair to enter growth phase

learn Overview

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