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    Glossary Stem Cell Loss

    reduction of regenerative cells impairing tissue repair and growth

    Stem cell loss refers to the reduction or depletion of stem cells in a particular tissue or organ. Stem cells are crucial for regenerating and repairing tissues, so their loss can lead to impaired healing and tissue degeneration. In the context of hair, stem cell loss in hair follicles can contribute to conditions like alopecia, where hair growth is significantly reduced or halted.

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    1. Deletion of the Developmentally Essential Gene ATR in Adult Mice Leads to Age-Related Phenotypes and Stem Cell Loss Cell Stem Cell · 2007 · 688 citations
    2. Adipose derived stem cell based therapies or male/female pattern hair loss Journal of stem cell research and medicine · 2016 · 1 citations
    3. Adipose derived stem cell based therapies or male/female pattern hair loss Journal of stem cell research and medicine · 2016 · 1 citations
    4. Clinical and Histopathological Features of Hair Loss in 17 Japanese Patients With Hematologic Disorders Following Hematopoietic Stem Cell Transplantation and Chemotherapy: A Case Series. PubMed · 2025
    5. A preliminary result of adipose derived stem cell treatment for female pattern hair loss Journal of Cosmetic Dermatology · 2021
    6. Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth-Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development Cells · 2019 · 136 citations
    7. Stem cell therapy and hair loss: Present evidence and future perspectives Journal of Dermatology and Dermatologic Surgery · 2019 · 1 citations
    8. Effects of exosome from adipose‐derived stem cell on hair loss: A retrospective analysis of 39 patients Journal of cosmetic dermatology · 2022 · 10 citations
    9. Advances in Stem Cell-Based Therapy for Hair Loss. PubMed · 2020 · 7 citations
    10. Stem cell therapy alleviates hair loss caused by COVID-19 vaccination Journal of Exercise Rehabilitation · 2026
    11. Review of Stem Cell Therapy for Hair Loss Journal of Dermatology Research Reviews & Reports · 2024
    12. Clinical, Trichoscopic And Immunohistochemical Evaluation of Autologous Adipose Derived Adult Stem Cell Injection in the Treatment of Female Pattern Hair Loss QJM: An International Journal of Medicine · 2021
    13. From a stem-cell–centered to a niche-centered view: the core role of collagen networks in hair loss and hair follicle miniaturization Frontiers in Cell and Developmental Biology · 2026
    14. Stem Cell therapy for Hair Loss Medical & Clinical Research · 2025
    15. Stem Cell-Based Therapies for Hair Loss: What is the Evidence from a Clinical Perspective? Stem cell biology and regenerative medicine · 2022
    16. Stem cell plasticity enables hair regeneration following Lgr5+ cell loss Nature Cell Biology · 2017 · 56 citations
    17. Stem cell secretome as a mechanism for restoring hair loss due to stress, particularly alopecia areata: narrative review Journal of Biomedical Science · 2022 · 2 citations
    18. Topical RT1640 treatment effectively reverses gray hair and stem cell loss in a mouse model of radiation‐induced canities Pigment cell & melanoma research · 2020 · 7 citations
    19. THE EFFECT OF HAIR TONIC FROM SECRETOME MESENCHYMAL STEM CELL ON HAIR GROWTH IN HAIR LOSS CASES International Journal of Applied Pharmaceutics · 2026
    20. Stem Cell-Based Hair Cell Regeneration and Therapy in the Inner Ear Neuroscience Bulletin · 2023 · 26 citations
    21. Hair shaft miniaturization causes stem cell depletion through mechanosensory signals mediated by a Piezo1-calcium-TNF-α axis Cell Stem Cell · 2021 · 23 citations
    22. Sequential Scalp Assessment in Hair Regeneration Therapy Using an Adipose-Derived Stem Cell–Conditioned Medium Dermatologic Surgery · 2019 · 33 citations
    23. Permanent diffuse alopecia after haematopoietic stem cell transplantation in childhood Bone Marrow Transplantation · 2017 · 16 citations
    24. Adipose-Derived Stem Cells and Their Secretory Factors for Skin Aging and Hair Loss Springer eBooks · 2016
    25. C3-C4 shingles post haematopoietic stem-cell transplantation Archives of disease in childhood · 2014
    26. The Modulatable Stem Cell Niche: Tissue Interactions during Hair and Feather Follicle Regeneration Journal of Molecular Biology · 2015 · 66 citations
    27. Cytoprotective role of human dental pulp stem cell-conditioned medium in chemotherapy-induced alopecia Stem cell research & therapy · 2024
    28. Mesenchymal stem cell-derived exosomes ameliorate gentamicin-induced vestibular hair cell injury by regulating the SNARE pathway and enhancing autophagy Stem Cell Research & Therapy · 2025 · 1 citations
    29. The anti‐apoptotic Bcl‐2 protein regulates hair follicle stem cell function EMBO Reports · 2021 · 10 citations
    30. Stem Cell Applications in Human Hair Growth: A Literature Review Cureus · 2023 · 8 citations