Calcium Channel Inhibitor and Extracellular Calcium Improve Aminoglycoside-Induced Hair Cell Loss in Zebrafish

April 2024 in “ Archives of toxicology ”

Liao-Chen Chen, Hwei‐Hsien Chen, Ming‐Huan Chan

calcium channel inhibitor extracellular calcium aminoglycoside antibiotics hair cell loss zebrafish

TLDR Certain substances can protect against ear damage from some antibiotics in zebrafish.

The study "Calcium channel inhibitor and extracellular calcium improve aminoglycoside-induced hair cell loss in zebrafish" investigated the effects of calcium channel inhibitors and extracellular calcium on aminoglycoside-induced hair cell loss in zebrafish. The researchers found that both calcium channel inhibitors and extracellular calcium significantly reduced hair cell loss caused by aminoglycoside antibiotics. The study involved 200 zebrafish and used aminoglycoside antibiotics, known to cause hair cell loss, to test the protective effects of calcium channel inhibitors and extracellular calcium. The results suggest that these substances could potentially be used to prevent hair cell loss in humans caused by aminoglycoside antibiotics.

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