44 citations
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March 2016 in “Frontiers in cellular neuroscience” In this study using zebrafish, four bisbenzylisoquinoline derivatives were found to protect hair cells from aminoglycoside-induced damage without reducing antibiotic efficacy, potentially leading to therapies for patients undergoing such treatments.
April 2024 in “Archives of toxicology” Certain substances can protect against ear damage from some antibiotics in zebrafish.
66 citations
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February 2015 in “Cell & tissue research/Cell and tissue research” This review explores the mechanisms of hair cell death due to factors like noise, ototoxic drugs, and aging and reports no conclusive clinical results; ongoing research may eventually enable preventive treatments for hearing loss.
4 citations
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December 2022 in “Frontiers in cell and developmental biology” This review discusses the use of zebrafish larvae as an alternative model for studying ototoxicity, facilitating large-scale screening for otoprotective compounds, but reports no new clinical results.
August 2023 in “JOJ dermatology & cosmetics” This literature review found that antibiotics are a major cause of cutaneous adverse drug reactions, which represent up to 60% of all adverse drug reactions, and emphasized the need for clinicians to better understand and manage these reactions.