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research Bioactive Molecules for Skin Repair and Regeneration: Progress and Perspectives
Bioactive molecules show promise for improving skin repair and regeneration by overcoming current challenges with further research.
research Wnt Target Gene Ascl4 Is Dispensable for Skin Appendage Development
The gene Ascl4 is not necessary for the development of hair, teeth, or mammary glands.
research Direct Reprogramming of Mouse Fibroblasts into Dermal Papilla Cells via Small Molecules
Scientists turned mouse skin cells into hair-inducing cells using chemicals, which could help treat hair loss.
research Changes in the Expression of Smooth Muscle Cell-Related Genes in Human Dermal Sheath Cup Cells Associated with the Treatment Outcome of Autologous Cell-Based Therapy for Male and Female Pattern Hair Loss
Lower levels of certain genes in hair cells improve hair loss treatment outcomes.
research The Metabolites of Bifidobacterium Longum BB536 Alleviate DHT-Damaged Human Dermal Papilla Cells by Activating WNT/β-Catenin Signaling
Bifidobacterium longum BB536 metabolites may help treat hair loss by repairing and promoting hair cell growth.
research Hair Growth-Promoting Mechanisms of Red Ginseng Extract Through Stimulating Dermal Papilla Cell Proliferation and Enhancing Skin Health
Red Ginseng Extract helps hair grow and improves skin health by stimulating cell growth and enhancing the body's antioxidant defense system.
research Malva Verticillata Seed Extracts Upregulate the Wnt Pathway in Human Dermal Papilla Cells
Malva verticillata seed extract might help treat hair loss by activating hair growth signals in skin cells.
research Hair Follicle Development of Rex Rabbits Is Regulated Seasonally by Wnt10b/β-Catenin, TGFβ-BMP, IGF1, and EGF Signaling Pathways
Winter provides the best fur quality for Rex rabbits due to seasonal changes in specific signaling pathways.
research Revisiting the Role of Melatonin in Human Melanocyte Physiology: A Skin Context Perspective
Melatonin affects skin and hair color and protects skin cells, with potential benefits for hair growth and skin health.
research Management of Colorectal Cancer Using Nanocarrier-Based Drug Delivery for Herbal Bioactives: Current and Emerging Approaches
Nanocarriers can improve the effectiveness of herbal medicines in treating colorectal cancer.
research Stem Cell Secretome as a Mechanism for Restoring Hair Loss Due to Stress, Particularly Alopecia Areata: Narrative Review
Stem cells and their secretions could potentially treat stress-induced hair loss, but more human trials are needed.
research Melatonin Protects K15+ Human Hair Follicle Stem Cells and Hair Matrix Keratinocytes Against Paclitaxel-Induced Damage Ex Vivo
Melatonin may protect hair follicle cells from damage caused by a chemotherapy drug.
research Partial Proteasome Inhibitors Induce Hair Follicle Growth by Stabilizing Beta-Catenin
Certain inhibitors applied to the skin can promote hair growth by maintaining a key hair growth signal.
research Identifying the Target Cells and Mechanisms of Merkel Cell Polyomavirus Infection
Human dermal fibroblasts are the main cells targeted by a virus that can cause a deadly skin cancer, and a certain inhibitor can effectively block this infection.
research Intrinsic Activation of Cell Growth and Differentiation in Ex Vivo Cultured Human Hair Follicles by a Transient Endogenous Production of ROS
Temporary ROS production in cultured human hair follicles promotes growth and stem cell activation.
research The Role of Lysophosphatidic Acid in the Physiology and Pathology of the Skin
Lysophosphatidic acid is important for skin health and disease, and could be a target for new skin disorder treatments.
research Scoparone Induces Expression of Pluripotency Transcription Factors SOX2 and NANOG in Dermal Papilla Cells
Scoparone may help stimulate hair growth by increasing stem cell-related proteins in skin cells.
research HaCaT-Conditioned Medium Supplemented with Small Molecule Inhibitors SB431542 and CHIR99021 and Growth Factor PDGF-AA Prevents the Dedifferentiation of Dermal Papilla Cells In Vitro
A mix of specific inhibitors and a growth factor helps keep hair growth cells from losing their properties in the lab.
research PKC Downregulation Upon Rapamycin Treatment Attenuates Mitochondrial Disease
Rapamycin treatment helps with mitochondrial disease by reducing PKC levels.
research Protein Kinase C Is a Key Target for Attenuation of Leigh Syndrome by Rapamycin
Rapamycin may help treat Leigh syndrome by targeting protein kinase C.
research NF-κB in Biology and Targeted Therapy: New Insights and Translational Implications
NF-κB signaling is crucial in many diseases and can be targeted for new treatments.
research Effect of 5-Alpha Reductase Inhibitors in Animal Models of Parkinson's Disease
5-alpha reductase inhibitors may help protect the brain and gut in Parkinson's disease.
research MTOR Signaling in Hair Follicle and Hair Diseases: Recent Progress
The mTOR signaling pathway is crucial for hair health and targeting it may lead to new hair loss treatments.
research Molecular Principles of Hair Follicle Induction and Morphogenesis
Hair follicle development is controlled by interactions between skin tissues and specific molecular signals.
research TCL1 Transgenic Mouse Model as a Tool for the Study of Therapeutic Targets and Microenvironment in Human B-Cell Chronic Lymphocytic Leukemia
The TCL1 transgenic mouse model is useful for understanding human B-cell leukemia and testing new treatments.
research WNT10A, Dermatology and Dentistry
Mutations in the WNT10A gene can cause skin, hair, teeth, and other disorders, and may also affect other areas like kidney and cancer, with potential for targeted treatments.
research Metabolic Pathways of Eicosanoids: Derivatives of Arachidonic Acid and Their Significance in Skin
Eicosanoids are crucial for skin health, and targeting their pathways may help treat skin conditions.
research Enzymes
Enzymes are classified into six types and are essential for many biological processes, with only a few targeted by drugs.
research Protein Degradation: Expanding the Toolbox to Restrain Cancer Drug Resistance
Using protein degradation to fight cancer drug resistance shows promise but needs more precise targeting and fewer side effects.