Wnt Target Gene Ascl4 Is Dispensable for Skin Appendage Development

    January 2024 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Verdiana Papagno, Ana-Marija Sulic, Jyoti Prabha Satta, Aida Kaffash Hoshiar, Vinod Kumar, Jukka Jernvall, Marja L. Mikkola
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    TLDR The gene Ascl4 is not necessary for the development of hair, teeth, or mammary glands.
    The study identifies Achaete-scute complex-like 4 (Ascl4) as a new target of the Wnt/β-catenin signaling pathway, which is crucial for the development of skin appendages such as hair follicles and teeth. Despite Ascl4's expression in the signaling centers of these appendages, the study reveals that mice lacking Ascl4 exhibit no noticeable defects in the morphogenesis of hair follicles, teeth, or mammary glands. This suggests that Ascl4 is not essential for the development of these structures and implies that other transcription factors might compensate for its absence. Further research is needed to explore this compensatory mechanism.
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