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GnRH analogues are effective for diagnosing and treating female androgen excess, offering a non-surgical option.

Women with regular menstrual cycles and PCOS have linked kisspeptin and LH hormone patterns, unlike those with irregular cycles.

The document explains how male reproductive hormones work and affect the body.

The conclusion is that PCOS is caused by ovarian sensitivity to hormones and disrupted hormone control, possibly due to ovarian factors, and more research is needed.

Cyproterone acetate is the preferred treatment for women's hyperandrogenism when estrogen/progestogen use is safe.

More research is needed to understand how testosterone is maintained in adult males.

PCOS is a genetic disorder affecting women's reproductive health, with treatments focused on symptoms like insulin resistance and fertility.

The document concludes that early and personalized treatment for PCOS in adolescents is crucial to manage symptoms and prevent long-term health issues.

Hormone therapy for transgender females increases the risk of blood clots and requires careful dosing, monitoring, and lifelong management.

Hormone therapy affects hair growth in transgender individuals, with testosterone potentially causing hair loss in trans men and estrogen reducing facial/body hair in trans women; treatment options vary.

The conclusion is that while oral contraceptive pills are effective for PCOS-related high androgen levels, new treatments with fewer side effects are needed.

Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

Chemicals and body size might change when puberty starts and progresses, but more research is needed to confirm this.

Polycystic Ovary Syndrome likely starts in childhood and may be genetic and influenced by early hormone exposure.

The safety and effectiveness of gender-affirming treatments for children are uncertain, with potential long-term risks like infertility.

High androgen levels in postmenopausal women may suggest an ovarian tumor, and removing it can improve heart and metabolic health.

Effective, well-tolerated, and affordable treatments are needed for recurrent ischemic priapism.

Clofazimine may be effective for treating ashy dermatosis.

Clofazimine successfully treated a man's ashy dermatosis, clearing his skin lesions.

Hormone imbalances from the pituitary, thyroid, and adrenal glands can cause infertility, but treating these disorders can improve fertility.

Treatment of acromegaly can improve women's reproductive health issues caused by hormonal imbalances or tumors.

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

PCOS affects women's health by increasing the risk of diabetes, heart disease, and reproductive issues.

A postmenopausal woman's increased male hormone levels were successfully treated with surgery.

Antiandrogens and androgen inhibitors like spironolactone, finasteride, and dutasteride can treat hair loss and skin conditions, but they have risks and side effects, including potential harm to pregnant women and risks of cancer and heart issues. Herbal remedies also have antiandrogenic effects but lack safety validation.

Agaricus subrufescens improves ovarian function and biochemical health in rats with PCOS.

Certain gene variants may contribute to high androgen levels in women with polycystic ovary syndrome.

The new rodent model successfully mimics non-lean human PCOS symptoms.

The document says PCOS is a common hormonal disorder in women, diagnosed by certain criteria, and managed with lifestyle changes and various medications.

The conclusion suggests that prostate cancer should be classified by castration status and that new therapies targeting androgen receptor signaling show promise.