Menopausal Androgen Excess-Associated Cardio-Metabolic Risk: Clues for Ovarian Leydig Cell Tumor (Case Report and Mini-Review of Literature)

January 2017 in “ Acta Endocrinologica ”

Ancuta Augustina Gheorghisan‐Galateanu, Dana Terzea, Ana Valea, Mara Cârșote

androgen excess Leydig cell tumour hyperandrogenism testosterone virilisation hysterectomy bilateral salpingo-oophorectomy androgen hormones high testosterone ovarian tumor high androgen levels male characteristics removal of uterus removal of ovaries male hormones

Studysummary This case report discusses a postmenopausal woman whose hyperandrogenism and metabolic symptoms improved significantly after the surgical removal of an ovarian Leydig cell tumor, confirmed post-operatively.

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research Cardiovascular Risk Factors and Events in Women with Androgen Excess

31 citations , November 2014 in “Journal of Endocrinological Investigation”

This article reviews androgen excess and cardiometabolic risks in women, highlighting increased cardiovascular disease risk in those with polycystic ovary syndrome, but reports no new clinical results.

research Sertoli-Leydig Cell Tumors: Hormonal Profile After Dynamic Test with GnRH Analogue Triptorelin Represents a Useful Tool to Evaluate Tumoral Hyperandrogenism

5 citations , October 2014 in “Gynecological Endocrinology”

This case study describes a 15-year-old girl with a Sertoli–Leydig cell tumor who showed high androgen levels and steroidogenic responses similar to patients with polycystic ovary syndrome before surgery.

research Management of Endocrine Disease: Hyperandrogenism After Menopause

84 citations , September 2014 in “European journal of endocrinology”

This review examines the causes and characteristics of androgen excess in postmenopausal women, but reports no new clinical results; the authors emphasize challenges in diagnosis and potential long-term health impacts.

research Ovarian Leydig Cell Tumor in a Post-Menopausal Patient with Severe Hyperandrogenism

22 citations , February 2014 in “Arquivos Brasileiros De Endocrinologia E Metabologia”

An 81-year-old woman's severe male hormone symptoms were caused by an ovarian tumor, which was treated with surgery.

research Occult Ovarian Leydig Cell Tumor: When Laboratory Tells More Than Imaging

5 citations , October 2013 in “Endocrine”

This case report describes three instances where occult ovarian Leydig cell tumors were suspected based on severe hyperandrogenism symptoms, despite negative imaging findings, highlighting that elevated testosterone levels are a crucial diagnostic marker.

No Metabolic Impact of Surgical Normalization of Hyperandrogenism in Postmenopausal Women with Ovarian Androgen-Secreting Tumors

research No Metabolic Impact of Surgical Normalization of Hyperandrogenism in Postmenopausal Women with Ovarian Androgen-Secreting Tumors

17 citations , May 2012 in “Clinical Endocrinology”

This study found that surgical normalization of testosterone in hyperandrogenic women with ovarian androgen-secreting tumors did not significantly change body weight or insulin sensitivity after 12 months.

research Gonadotropin-Releasing Hormone Agonist Treatment in Postmenopausal Women with Hyperandrogenism of Ovarian Origin

36 citations , May 2011 in “The Journal of Clinical Endocrinology & Metabolism”

Treatment with a hormone agonist can reduce excess male hormones in postmenopausal women without surgery.