Sertoli-Leydig Cell Tumors: Hormonal Profile After Dynamic Test with GnRH Analogue Triptorelin Represents a Useful Tool to Evaluate Tumoral Hyperandrogenism

October 2014 in “ Gynecological Endocrinology ”

Jenni Turra, Marnie Granzotto, M Gallea, Diego Faggian, Lorena Conte, Pietro Litta, Roberto Vettor, Roberto Mioni

Sertoli-Leydig cell tumor hyperandrogenism testosterone GnRH analogue triptorelin ovarian steroids steroidogenesis virilization differential diagnosis PCOS SLCT GnRH

TLDR Triptorelin helps evaluate hormone production in Sertoli-Leydig cell tumors.

The document describes a case study of a 15-year-old female with a Sertoli-Leydig cell tumor (SLCT) causing hyperandrogenism. Elevated testosterone levels were observed, and a GnRH-analogue test with triptorelin showed an exaggerated secretion of ovarian steroids. The patient's hormonal levels were significantly higher compared to healthy women and similar to those of healthy men and PCOS patients. After tumor removal, her hormonal levels decreased, and virilization symptoms were reduced. The study suggests that the GnRH-analogue test is a useful tool for characterizing steroidogenesis in SLCT and may assist in differential diagnosis. It also indicates that SLCTs may respond to physiological stimuli like GnRH analogue, which could have therapeutic implications. The document highlights the importance of considering SLCT in the differential diagnosis of virilization symptoms in reproductive-age women. The number of participants in the study is not mentioned.

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