TLDR The document concludes that early and personalized treatment for PCOS in adolescents is crucial to manage symptoms and prevent long-term health issues.
The document from 2013 provides insights into the diagnosis and treatment of Polycystic Ovary Syndrome (PCOS) in adolescents from the perspectives of a pediatric endocrinologist and a pediatric gynecologist. It notes that PCOS affects 4-12% of women of reproductive age and can lead to various health issues, including endometrial pathology, obesity, insulin resistance, and hyperandrogenemia. The prevalence among adolescents is around 3% based on an Iranian study. The disorder's pathogenesis is linked to genetic factors and disruptions in the hypothalamic-pituitary-gonadal axis. Clinically, PCOS presents with menstrual abnormalities and signs of hyperandrogenemia, such as hirsutism, acne, and alopecia. The document emphasizes the importance of accurate diagnosis, which relies on the presence of hyperandrogenism, chronic anovulation, and polycystic ovaries, and suggests that laboratory evaluation is crucial despite the absence of a definitive endocrine marker. Treatment focuses on managing symptoms and preventing comorbid conditions, with low-dose combination oral contraceptive pills (COCs) being effective for menstrual regulation and antiandrogen therapy for hirsutism. Lifestyle interventions are recommended for obesity management, and insulin-sensitizing agents may be used for insulin resistance. The document highlights the need for individualized care and the importance of early treatment to mitigate long-term health consequences.
815 citations,
April 2010 in “The Journal of Clinical Endocrinology & Metabolism” Women with PCOS should be screened for heart disease risk and manage their health to prevent it.
67 citations,
February 2010 in “Acta Obstetricia et Gynecologica Scandinavica” Hirsutism is a strong sign of high male hormones and metabolic problems in women with PCOS, but acne and hair loss are not.
373 citations,
September 2009 in “Obstetrics & Gynecology” The bulletin provides guidelines for diagnosing and managing PCOS, suggesting weight loss, hormonal contraceptives, and diabetes screening, with clomiphene for infertility and various treatments for excess hair.
50 citations,
February 2007 in “Clinical obstetrics and gynecology” Early detection and treatment of PCOS in teenagers is important to manage symptoms and prevent severe issues.
1744 citations,
August 2006 in “The Journal of Clinical Endocrinology and Metabolism” Polycystic Ovary Syndrome should be seen mainly as a condition of excess male hormones, with a focus on this in its definition.
131 citations,
August 2004 in “Best Practice & Research in Clinical Obstetrics & Gynaecology” The conclusion is that PCOS is caused by ovarian sensitivity to hormones and disrupted hormone control, possibly due to ovarian factors, and more research is needed.
4025 citations,
December 2003 in “Human Reproduction” The 2003 consensus updated PCOS diagnosis criteria and linked PCOS to higher risks of diabetes and heart problems, recommending lifestyle changes to lower these risks.
418 citations,
June 2003 in “Endocrine Reviews” While PCOS might increase the risk of heart disease, there's not strong evidence to prove it causes earlier heart problems.
89 citations,
March 2001 in “Endocrine practice” The guidelines help doctors diagnose and treat hormone-related disorders in women.
PCOS is a common hormonal disorder with symptoms like irregular periods and excess hair growth, managed with lifestyle changes and medications.
June 2023 in “Journal of multidisciplinary sciences” PCOS may increase the risk of certain cancers.
November 2022 in “The Journal of Clinical Endocrinology and Metabolism” Postmenopausal hyperandrogenism, a condition with symptoms like increased hair growth and acne, is usually caused by PCOS but can also be due to other factors. It's diagnosed by checking testosterone levels and treated either by removing the adrenal tumor or through antiandrogen therapy.
June 2023 in “Journal of multidisciplinary sciences (Online)” PCOS is linked to a higher risk of endometrial cancer but not ovarian or breast cancer, and more research is needed on its role in cancer development and treatment effects.
9 citations,
January 2015 in “Springer eBooks” The document concludes that managing PCOS involves treating symptoms, regulating periods, and reducing health risks, with specific medications for fertility and metabolic issues.
