Clinical Utility of GnRH Analogues in Female Androgen Excess: Highlighting Diagnostic and Therapeutic Applications

This document discusses the clinical utility of GnRH analogues in diagnosing and treating female androgen excess, particularly in cases of ovarian hyperandrogenism. It presents three cases: one involving postmenopausal androgen excess resolved by resecting a benign ovarian tumor after GnRH analogue testing; another showing GnRH analogues' dual role in diagnosing and treating hyperandrogenism in a premenopausal woman with severe insulin resistance, leading to reduced serum testosterone and improved hirsutism; and a third case where GnRH analogue suppression successfully treated a postmenopausal woman with ovarian hyperthecosis, avoiding surgery. The case series highlights GnRH analogues as a valuable tool for managing refractory androgen excess and as a non-surgical alternative for benign ovarian hyperandrogenism.