Development and Evaluation of Novel Rodent Model of PCOS Mimicking Clinical Phenotype in Human Disease

    August 2022 in “ Middle East Fertility Society Journal ”
    Santhana Kumar, Pravin Tirgar, Mittal Dalal
    TLDR The new rodent model successfully mimics non-lean human PCOS symptoms.
    The study developed a novel rodent model for non-lean type polycystic ovary syndrome (PCOS) by administering dihydrotestosterone (DHT) and fructose to prepubertal SD rats. Over 90 days, these rats exhibited increased serum testosterone, luteinizing hormone (LH), estradiol, decreased follicle-stimulating hormone (FSH) levels, and multiple cystic follicles, mimicking human PCOS phenotypes. The model also showed increased abdominal and subcutaneous fat, ovary, and uterine weight, along with impaired insulin sensitivity and glucose tolerance. The DHT and fructose combination effectively replicated the clinical features of non-lean PCOS, suggesting its potential as a novel rodent model for studying this condition.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 164 results

      community Pre-Finisteride DHT & Hormone Blood Panel

      in Finasteride/Dutasteride  3 upvotes 3 weeks ago
      The conversation discusses the cost and insurance coverage of a comprehensive hormone and DHT blood panel for hair loss, with a focus on finasteride treatment. The user seeks a cheaper alternative to a $700 panel recommended in a video.

      community Interpreting pre-finisteride blood panels

      in Chat  2 upvotes 1 week ago
      The conversation is about someone planning to start finasteride for hair loss and wanting to interpret pre-treatment blood panels to assess the risk of side effects like gynecomastia. They list various tests to measure hormone levels and other health indicators.

      community Why is it that low testosterone causes hair loss as well? How can I be balding?

      in Chat  158 upvotes 1 year ago
      The conversation discusses the confusion over low testosterone potentially causing hair loss, with users sharing personal experiences and knowledge about hair loss treatments like Finasteride. Some users suggest that hair follicle sensitivity to DHT, not testosterone levels, is the key factor in balding, and others discuss the side effects of hair loss medications.

    Related Research

    4 / 4 results