Development and Evaluation of Novel Rodent Model of PCOS Mimicking Clinical Phenotype in Human Disease

    August 2022 in “ Middle East Fertility Society Journal ”
    Santhana Kumar, Pravin Tirgar, Mittal Dalal
    TLDR The new rodent model successfully mimics non-lean human PCOS symptoms.
    The study developed a novel rodent model for non-lean type polycystic ovary syndrome (PCOS) by administering dihydrotestosterone (DHT) and fructose to prepubertal SD rats. Over 90 days, these rats exhibited increased serum testosterone, luteinizing hormone (LH), estradiol, decreased follicle-stimulating hormone (FSH) levels, and multiple cystic follicles, mimicking human PCOS phenotypes. The model also showed increased abdominal and subcutaneous fat, ovary, and uterine weight, along with impaired insulin sensitivity and glucose tolerance. The DHT and fructose combination effectively replicated the clinical features of non-lean PCOS, suggesting its potential as a novel rodent model for studying this condition.
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