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Pemetrexed is as effective as docetaxel but has fewer side effects for treating nonsmall-cell lung cancer after EGFR-TKI therapy failure.

Certain treatments can increase protein binding to natural hair but are less effective on permed hair.

Nanomaterials can improve hair care products and treatments, including hair loss and alopecia, by enhancing stability and safety, and allowing controlled release of compounds, but their safety in cosmetics needs more understanding.

B2m-free HLA variants may be a new class of HLA important in immune responses and diseases.

Early treatment of Lupus Erythematosus Alopecia can prevent permanent hair loss, and various medications are effective.

Chitosan scaffolds with silver nanoparticles effectively treat infected wounds and promote faster healing.

Tetrathiomolybdate reduces hair growth marker in skin cells by boosting harmful oxygen molecules, but effects can be reversed.

A new goat gene affects cashmere fiber thickness; certain variations can make the fibers coarser.

Nanotechnology could improve hair regrowth but faces challenges like complexity and safety concerns.

Peptide hydrogels show promise for healing skin, bone, and nerves but need improvement in stability and compatibility.

A patch with curcumin-zinc can improve hair growth and health by delivering beneficial particles to the skin, increasing hair follicles, and reversing effects of a hair loss hormone.

Seaweeds have beneficial compounds for skin care, including anti-aging and protective effects.

Two rare genetic diseases cause severe rickets in children due to defects in vitamin D metabolism.

Trichohyalin is modified by enzymes to form strong structures in hair cells.

Mutations in the RBPJ gene cause Adams-Oliver Syndrome.

Mutations in the vitamin D receptor cause hereditary vitamin D-resistant rickets, leading to poor bone health and requiring high calcium doses for treatment.

Chitosan, a natural substance, can be used to create tiny particles that effectively deliver various types of drugs, but more work is needed to improve stability and control of drug release.

High LGR5 levels in glioblastoma indicate poor prognosis and are essential for cancer stem cell survival.

Chemical hair straightening can damage hair and health, needing safer alternatives and stricter regulations.

Different STUB1 gene mutations cause varied symptoms in autosomal recessive ataxias.

Probiotics show promise for health benefits but need more research to understand how they work.

Future hair cosmetics will be safer and more effective.

Microneedle technology has advanced for painless drug delivery and sensitive detection but faces a gap between experimental use and clinical needs.

CD8+ T cells are involved in alopecia areata and may cause disease relapse.

Nanotube-based hair treatments could improve hair health and growth, and offer long-lasting effects.

The document concludes that understanding genetic mutations in the PI3K-AKT-mTOR pathway can lead to better diagnosis and treatment for certain genetic skin disorders.

Chinese domestic goats have unique genetic traits due to domestication and geographic isolation.

Genetic variations greatly affect individual metabolism and can impact health and disease risk.

Notch signaling disruptions can cause various skin diseases.

The new wound dressing helps skin heal faster and fights infection.