LGR5 Is a Marker of Poor Prognosis in Glioblastoma and Is Required for Survival of Brain Cancer Stem-Like Cells

    August 2012 in “ Brain pathology ”
    Susumu Nakata, Benito Campos, Josephine Bageritz, Justo Lorenzo Bermejo, Natália Becker, Felix B. Engel, Till Acker, Stefan Momma, Christel Herold‐Mende, Peter Lichter, Bernhard Radlwimmer, Violaine Goidts
    TLDR High LGR5 levels in glioblastoma indicate poor prognosis and are essential for cancer stem cell survival.
    The study concluded that LGR5 was a marker of poor prognosis in glioblastoma and essential for the survival of brain cancer stem-like cells (CSCs). LGR5 expression was significantly higher in CSCs compared to normal brain tissue and correlated with tumor aggressiveness and poor patient outcomes. Silencing LGR5 via lentiviral shRNA induced apoptosis in CSCs and downregulated key genes like L1CAM. Analysis of 283 astrocytic glioma samples showed that high LGR5 expression was linked to higher malignancy and worse prognosis. These findings suggested that targeting LGR5 could be a potential therapeutic strategy for glioblastoma treatment.
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