Search
for

    Glossary Gene Silencing

    reducing or preventing gene expression using various biological mechanisms

    Gene silencing, also known as gene suppression or gene knockdown, is a process by which the expression of a specific gene is reduced or entirely prevented. This can occur naturally through mechanisms like RNA interference (RNAi) or be induced artificially using techniques such as CRISPR-Cas9. It is a valuable tool in research and medicine for studying gene function and developing treatments for diseases, including those related to hair loss and alopecia.

    Related Terms

    Sort by

    Research 30 of 1000+

    1. Efficient Silencing of Androgen Receptor Gene via UTR-Targeting siRNAs for Androgenetic Alopecia Therapy Journal of Medicinal Chemistry · 2025
    2. Efficient Silencingof Androgen Receptor Gene viaUTR-Targeting siRNAs for Androgenetic Alopecia Therapy OPAL (Open@LaTrobe) (La Trobe University) · 2025
    3. From gene to therapy in spinal and bulbar muscular atrophy: Are we there yet? Molecular and Cellular Endocrinology · 2017 · 17 citations
    4. Correction of Hair Shaft Defects through Allele-Specific Silencing of Mutant Krt75 Journal of Investigative Dermatology · 2015 · 6 citations
    5. Role of the ABCA4 Gene Expression in the Clearance of Toxic Vitamin A Derivatives in Human Hair Follicle Stem Cells and Keratinocytes International journal of molecular sciences · 2023
    6. Comprehensive transcriptome and methylome analysis delineates the biological basis of hair follicle development and wool-related traits in Merino sheep BMC Biology · 2021 · 112 citations
    7. Olfactory receptor OR2AT4 regulates human hair growth Nature Communications · 2018 · 82 citations
    8. Tyrosinase Depletion Prevents the Maturation of Melanosomes in the Mouse Hair Follicle PloS one · 2015 · 31 citations
    9. Spermine Lipid Assembled Nanoparticles for siRNA Delivery and Androgenetic Alopecia Therapy ACS Applied Materials & Interfaces · 2026
    10. Keratinocytes of the Upper Epidermis and Isthmus of Hair Follicles Express Hemoglobin mRNA and Protein 2023
    11. 364 Mechanical forces of human dermal fibroblasts significantly decrease with age Journal of Investigative Dermatology · 2021
    12. Do Changes in Chromosomes Cause Aging? Cell · 1996 · 50 citations
    13. Double Knockdown of the Androgen Receptor Target Genes DKK1 and SFRP1 Does Not Potentiate the Hair Growth-Promoting Effect of SFRP1 Silencing in Healthy Human Hair Follicles Ex Vivo International Journal of Molecular Sciences · 2026
    14. Regulation of feather follicle development and Msx2 gene SNP degradation in Hungarian white goose BMC Genomics · 2022 · 1 citations
    15. Keratin disorders: from gene to therapy 2011 · 109 citations
    16. Hypoxia inducible factor-1α promotes trichogenic gene expression in human dermal papilla cells Scientific Reports · 2023 · 2 citations
    17. Knockout of p16INK4a promotes aggregative growth of dermal papilla cells Revista Da Associacao Medica Brasileira · 2017 · 2 citations
    18. RNA interference of NtNCED3 reduces drought tolerance and impairs plant growth through feedback regulation of isoprenoids in Nicotiana tabacum Environmental and Experimental Botany · 2018 · 17 citations
    19. Importance of microRNAs in skin morphogenesis and diseases. PubMed · 2008 · 70 citations
    20. Epidermal Stem Cells Are Defined by Global Histone Modifications that Are Altered by Myc-Induced Differentiation PLoS ONE · 2007 · 98 citations
    21. Primary care obstetrics and perinatal health Health Policy · 1991
    22. Skin transcriptome reveals the intrinsic molecular mechanisms underlying hair follicle cycling in Cashmere goats under natural and shortened photoperiod conditions Scientific reports · 2017 · 24 citations
    23. LncRNA-599547 contributes the inductive property of dermal papilla cells in cashmere goat through miR-15b-5p/Wnt10b axis Animal biotechnology · 2020 · 7 citations
    24. miR-200a Targets PITX2 to Mediate Goose Fibroblast Proliferation Through the Wnt Pathway Animals · 2025
    25. UDP-GlcNAc-1-Phosphotransferase Is a Clinically Important Regulator of Human and Mouse Hair Pigmentation Journal of Investigative Dermatology · 2021 · 10 citations
    26. Clinically relevant aberrant Filip1l DNA methylation detected in a murine model of cutaneous squamous cell carcinoma EBioMedicine · 2021 · 7 citations
    27. Clinical Snippets Journal of Investigative Dermatology · 2016
    28. Topobiology of Human Pigmentation: P-Cadherin Selectively Stimulates Hair Follicle Melanogenesis 2013 · 29 citations
    29. MiRNA-24 downregulates KLF6 affecting STAT3 protein expression and phosphorylation regulating melanogenesis in cashmere goat coat Animal Bioscience · 2025
    30. 102 Methylation of CpG islands in promoter of type 2 5-α reductase and implications of finasteride resistance for BPH therapy European Urology Supplements · 2016