Role of the ABCA4 Gene Expression in the Clearance of Toxic Vitamin A Derivatives in Human Hair Follicle Stem Cells and Keratinocytes
May 2023
in “
International journal of molecular sciences
”
ABCA4 gene toxic Vitamin A derivatives human hair follicle stem cells keratinocytes all-trans-retinal epidermis hair follicle cells metabolic intermediates progeny features silencing the ABCA4 gene proliferation rate alopecia Vitamin A derivatives hair stem cells skin cells retinal skin layer hair cells metabolic byproducts cell offspring gene silencing cell growth rate hair loss
TLDR The ABCA4 gene protects hair follicle stem cells from toxic vitamin A byproducts.
The study investigated the role of the ABCA4 gene in the clearance of toxic Vitamin A derivatives in human hair follicle stem cells and keratinocytes. The ABCA4 gene, which is strongly expressed in the basal layer of the epidermis and in hair follicle cells, was found to protect these cells from the accumulation of metabolic intermediates, thus maintaining their progeny features. The study also found that silencing the ABCA4 gene increased the toxic effects of all-trans-retinal (a Vitamin A derivative) on human hair follicle stem cells, reducing their proliferation rate to about 45%. However, treatment with all-trans-retinal induced the expression of the ABCA4 gene in these cells. These findings suggest that the ABCA4 gene plays a significant role in the metabolism of Vitamin A derivatives in human hair follicle stem cells and keratinocytes, which may have implications for hair growth and alopecia.
