103 citations
,
June 2018 in “International Journal of Molecular Sciences” This review discusses the applications and research on fibroblast growth factors, including their use in wound healing, diabetes, and cancer, but it reports no new clinical results.
1 citations
,
September 2016 in “Journal of Dermatological Science” This study found that FGF18 signaling helps protect hair follicles from radiation damage by maintaining the resting phase and supporting stem cell survival, potentially reducing radiation-induced hair loss.
3 citations
,
May 2019 in “Journal of Cosmetic Dermatology” This study suggests that the dipeptide Pro-Ile has FGF18-like activity, can penetrate model human epidermis, and may have potential as a cosmetic ingredient for skin and hair regulation.
3 citations
,
January 2007 in “Nishinihon hifuka/Nishi Nihon hifuka” This study found that Sanguisorba Officinalis Root Extract showed potential in reducing hair loss by inhibiting FGF-5 activity, extending hair growth phases in mice and reducing hair loss in human trials.
16 citations
,
January 2019 in “Pharmaceutical biology” This study found that Lespedeza cuneata aqueous extract reduced serum dihydrotestosterone levels and 5α-reductase mRNA expression in testosterone-induced prostatic hyperplasia in rats, suggesting potential as a treatment for prostatic hyperplasia.
65 citations
,
February 2009 in “The journal of investigative dermatology/Journal of investigative dermatology” This paper discusses the hypothesis that anti-acne agents may work by reducing FGFR2 signaling, and emphasizes FGFR2's potential role in acne pathogenesis, but it reports no new experimental findings.
1 citations
,
May 2003 in “The journal of investigative dermatology/Journal of investigative dermatology” This paper reviews several dermatological studies, including findings on hair growth, skin damage, bullous pemphigoid, and psoriasis treatments, and reports no new clinical results.
39 citations
,
May 2014 in “Frontiers in Pharmacology” In this study, CD4+CD25+FoxP3+ Regulatory T cells were found to reduce TGF-b1 induced lung fibrosis and fibrocyte accumulation in mice, partly by suppressing fibroblast growth factor 9.
18 citations
,
January 2017 in “Postępy Dermatologii i Alergologii” This review discusses the adverse skin effects of EGFR inhibitors used in cancer treatment, exploring their mechanisms and offering strategies for prevention and management, but reports no new experimental findings.
119 citations
,
November 2014 in “Trends in Cell Biology” This review discusses the mechanisms and pathways of FGFR signalling and its roles in development, disorders, and therapeutic targeting, but reports no new clinical results.
68 citations
,
April 2012 in “Journal of Investigative Dermatology” The study reports that Fgf18 and Tgf-β2 signaling pathways in hair follicle stem cells have opposing effects on the timing of hair cycle transitions, influencing the shift from telogen to anagen phases.
August 2016 in “Journal of Investigative Dermatology” This study reported improvement in hair loss lesions in C3H/HeJ mice with alopecia areata following treatment with the CCR5 inhibitor maraviroc, alongside reduced infiltration of specific T cells in the lesions.
January 2006 in “Advances in developmental biology” This review discusses the roles of the hairless (HR) protein as a corepressor, particularly its impact on RORα-mediated transcriptional repression, and reports no new experimental findings.
52 citations
,
May 2003 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that overexpression of parathyroid hormone-related protein in mice resulted in 30–40% shorter hair due to premature transition into the catagen phase of the hair cycle.
66 citations
,
February 2007 in “The journal of investigative dermatology/Journal of investigative dermatology” The researchers reported that adenosine increases FGF-7 expression in dermal papilla cells, which may stimulate hair growth via the A2b adenosine receptor and cAMP pathway.
97 citations
,
April 2016 in “Andrology” This review discusses the etio-pathogenetic factors in benign prostatic hyperplasia and their role in the development of lower urinary tract symptoms but reports no new research findings.
90 citations
,
October 1996 in “Dermatologic Clinics” This study found that red ginseng oil may enhance hair growth and protect skin from UV damage in mouse models by promoting regenerative processes and reducing inflammation.
11 citations
,
August 1997 in “Expert Opinion on Therapeutic Patents” This review discusses nearly 70 patent applications for the treatment of androgenetic alopecia and other hair conditions, highlighting the mechanisms of action explored but reports no clinical results.
174 citations
,
April 2005 in “The American journal of pathology (Print)” This study found that TRPV1 activation in human scalp hair follicles inhibited hair shaft elongation, suppressed proliferation, and induced apoptosis, suggesting TRPV1 as a potential target for managing hair growth and epithelial disorders.
98 citations
,
December 2008 in “Journal of Investigative Dermatology” This review discusses the possible impacts of prolactin on skin conditions like psoriasis, alopecia, and stress-related dermatoses, emphasizing the need for further research to explore its therapeutic potential.
32 citations
,
April 2016 in “Journal of Investigative Dermatology” This study found that STAT5 activation in the dermal papilla acts as a key switch to trigger anagen entry in postdevelopmental hair follicle cycling.
April 2018 in “Journal of Investigative Dermatology” This study identified a specific subset of macrophages as a key source of oncostatin M, maintaining hair follicle stem cell quiescence during the resting phase in mice, suggesting a potential target for treating hair disorders.
133 citations
,
May 2016 in “Cell Host & Microbe” In this study, human dermal fibroblasts were identified as natural host cells that support productive Merkel cell polyomavirus infection, and the MEK antagonist trametinib was introduced as an effective inhibitor to control the virus.
74 citations
,
September 2006 in “Cell Cycle” This review examines the role of Hairless, a nuclear receptor corepressor, in regulating Wnt signaling during hair cycling and reports no new clinical results.
53 citations
,
May 2010 in “Journal of Cellular Physiology” This study found that mice lacking the Vitamin D receptor showed disrupted hair follicle cycling, which was partially restored with hedgehog signaling pathway activation, suggesting a role for this pathway in follicle regulation independent of vitamin D.
1 citations
,
August 2016 in “Journal of Investigative Dermatology” This research reported that STAT5 activation in the dermal papilla plays a crucial role in triggering anagen entry during post-developmental hair follicle cycling.
December 2025 in “Biomedicines” This source reviews the common skin-related side effects of tyrosine kinase inhibitors in treating endocrine cancers and emphasizes that proactive, multidisciplinary management can effectively control these adverse events without compromising cancer treatment efficacy.
4 citations
,
April 2024 in “Cellular and Molecular Biology” In this study, injectable platelet-rich fibrin (i-PRF) was found to enhance the proliferative, migratory, and hair-inducing abilities of dermal papilla cells more effectively than platelet-rich plasma through the TGF-β/Smad pathway.
300 citations
,
August 2012 in “Seminars in Cell & Developmental Biology” This review discusses mesenchymal–epithelial interactions in hair follicle development and cycling, highlighting recent insights without reporting new experimental results.
January 2023 in “Kafkas üniversitesi veteriner fakültesi dergisi/Kafkas üniversitesi veteriner fakültesi dergisi” In this study of Angora goats, researchers found that HOXC13 and other genes were overexpressed during the active hair growth phase, suggesting a role in mohair structure.