Multiple Endocrine Defects in Adult-Onset Sprouty1/2/4 Triple Knockout Mice

    April 2024 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Gisela Altés, Anna Olomí, Aida Perramon-Güell, Sara Hernández, Anna Casanovas, Alicia Pérez, Juan Miguel Díaz-Tocados, José Manuel Valdivielso, Cristina Megino‐Luque, Raúl Navaridas, Xavier Matías‐Guiu, Ophir D. Klein, Joaquim Egea, Xavier Dolcet, Andrée Yeramian, Mario Encinas
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    TLDR Removing Sprouty genes in mice causes various hormone-related issues but does not increase cancer risk by one year of age.
    The study generated adult-onset Spry1/2/4 triple knockout mice to investigate the role of Sprouty genes in adult life. The findings revealed that the absence of Sprouty genes does not lead to an increased tumor incidence up to one year of age, suggesting that Sprouty loss alone is not enough to initiate cancer. However, the triple knockout mice exhibited several endocrine abnormalities, including no weight gain with age, reduced visceral fat, lower plasma glucose levels, alopecia, eyelid inflammation, mild hyperthyroidism, phosphaturia, and hypophosphatemia. These symptoms indicate that the loss of Sprouty genes leads to disrupted endocrine functions, potentially due to increased FGF23 signaling.
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