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    Glossary Estrogen Receptor Beta

    protein that binds estrogen and influences various biological processes

    Estrogen Receptor Beta (ERβ) is one of the two main types of receptors that bind to the hormone estrogen, the other being Estrogen Receptor Alpha (ERα). ERβ is involved in regulating various biological processes, including reproductive functions, bone density, and even hair growth. It plays a crucial role in mediating the effects of estrogen in different tissues, and its activity can influence conditions like alopecia, where hair loss occurs.

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    1. The Modulation of Aromatase and Estrogen Receptor Alpha in Cultured Human Dermal Papilla Cells by Dexamethasone: A Novel Mechanism for Selective Action of Estrogen via Estrogen Receptor Beta? Journal of Investigative Dermatology · 2006 · 65 citations
    2. Complex Extract of Polygonatum sibiricum and Nelumbinis semen Improves Menopause Symptoms via Regulation of Estrogen Receptor Beta in an Ovariectomized Rat Model Nutrients · 2023
    3. Hair Cycle Control by Estrogens: Catagen Induction via Estrogen Receptor (ER)-α Is Checked by ERβ Signaling Endocrinology · 2005 · 92 citations
    4. Association analysis of oestrogen receptor beta gene ( <i>ESR2</i> ) polymorphisms with female pattern hair loss British Journal of Dermatology · 2011 · 27 citations
    5. Early androgen activity after birth determines the hypothalamic expression of androgen and estrogen receptors in adulthood in female but not in male rats Reproductive Biology and Endocrinology · 2025
    6. An estrogen receptor pathway regulates the telogen-anagen hair follicle transition and influences epidermal cell proliferation. Proceedings of the National Academy of Sciences of the United States of America · 1996 · 154 citations
    7. Role of estrogen receptor signaling in the control of the hair follicle cycle 2004
    8. Pharmacological activation of estrogen receptors-α and -β differentially modulates keratinocyte differentiation with functional impact on wound healing International Journal of Molecular Medicine · 2015 · 23 citations
    9. Localization of sex steroid receptors in human skin. PubMed · 2004 · 147 citations
    10. Sex Steroid Hormone Receptors in Human Skin Appendage and its Neoplasms Endocrine Journal · 2005 · 59 citations
    11. Ovarian sex steroid receptors and sex hormones in androgenized rats Reproduction · 2016 · 13 citations
    12. Estrogen and androgen signaling in the pathogenesis of BPH Nature reviews. Urology · 2011 · 149 citations
    13. Current evidence for the involvement of sex steroid receptors and sex hormones in benign prostatic hyperplasia Research and Reports in Urology · 2019 · 26 citations
    14. The Distribution of Estrogen Receptor β Is Distinct to That of Estrogen Receptor α and the Androgen Receptor in Human Skin and the Pilosebaceous Unit Journal of Investigative Dermatology Symposium Proceedings · 2003 · 130 citations
    15. 17β-estradiol Inhibits the Production of RANTES in Human Keratinocytes Journal of Investigative Dermatology · 2003 · 56 citations
    16. 25 years of ERβ: a personal journey Journal of molecular endocrinology · 2021 · 11 citations
    17. Finasteride inhibits epinephrine synthesis in humans: implication for sexual dysfunction Endocrine Abstracts · 2022
    18. Large Scale Gene Expression Profiles of Regenerating Inner Ear Sensory Epithelia PLoS ONE · 2007 · 77 citations
    19. Regulation of human hair growth: hormones and neuropeptides 프로그램북(구 초록집) · 2016
    20. Reply from the Authors Journal of Investigative Dermatology · 1998
    21. Emerging medication for the treatment of male hypogonadism Expert Opinion on Emerging Drugs · 2012 · 77 citations
    22. Dutasteride‐mediated morphological changes in the genitourinary tract associated with altered expression patterns of the androgen and estrogen receptors in male rats Andrology · 2016 · 12 citations
    23. Polymorphisms of the Androgen Receptor Gene and the Estrogen Receptor β Gene Are Associated with Androgen Levels in Women1 The Journal of Clinical Endocrinology and Metabolism · 2001 · 93 citations
    24. Polymorphisms in androgen and estrogen receptor genes: effects on male aging Experimental Gerontology · 2004 · 12 citations
    25. Intrinsic versus Extrinsic Aging: A Histopathological, Morphometric and Immunohistochemical Study of Estrogen Receptor β and Androgen Receptor Skin Pharmacology and Physiology · 2016 · 9 citations
    26. Association of estrogen receptor gene variants (ESR1 and ESR2) with polycystic ovary syndrome in Tunisia Gene · 2020 · 9 citations
    27. Ferulic acid promotes hair growth via estrogen receptor alpha activation in cultured human dermal papilla cells Scientific Reports · 2026
    28. Effect of estrogens on skin aging and the potential role of selective estrogen receptor modulators Climacteric · 2007 · 67 citations
    29. Evaluation of the relationship between serum G protein-coupled estrogen receptors (GPER-1) levels and the severity and duration of the disease in patients with androgenetic alopecia: A case-control study Archives of Dermatological Research · 2024
    30. Estrogen Receptor α, but not Estrogen Receptor β, is Involved in the Regulation of the Hair Follicle Cycling as well as the Thickness of Epidermis in Male Mice Journal of Investigative Dermatology · 2002 · 72 citations