Finasteride Inhibits Epinephrine Synthesis in Humans: Implications for Sexual Dysfunction
May 2022
in “
Endocrine Abstracts
”
New to Finasteride? There is a guide in the encyclopedia. Read the guide → Studysummary Finasteride may cause sexual dysfunction by reducing epinephrine levels.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
Finasteride, a 5alpha-reductase inhibitor used for conditions like androgenetic alopecia, has been linked to sexual dysfunction, but the mechanisms were unclear. This study used in silico and in vitro methods to show that finasteride inhibits phenylethanolamine N-methyltransferase (PNMT), reducing epinephrine synthesis. In vivo experiments on rats treated with finasteride showed decreased epinephrine and increased norepinephrine levels in adrenal glands, along with decreased estrogen receptor beta and dopamine in corpora cavernosa, suggesting impaired erectile function. These findings provide a potential explanation for finasteride-induced sexual dysfunction in humans.
