Androgen Receptor Activation Integrates Complex Transcriptional Effects in Osteoblasts, Involving the Growth Factors TGF-β and IGF-I, and Transcription Factor C/EBPδ

July 2015 in “ Gene ”

Thomas L. McCarthy, Michael Centrella

dihydrotestosterone DHT androgen receptor AR TGF-β IGF-I C/EBPδ prostaglandin E2 PGE2 Smad Runx testosterone androgen transforming growth factor beta insulin-like growth factor I prostaglandin

TLDR DHT affects bone growth by altering gene activity in osteoblasts, potentially complicating steroid use.

The study demonstrated that dihydrotestosterone (DHT) suppressed IGF-I gene promoter activity in prostaglandin E2 (PGE2) induced osteoblasts through a C/EBP response element in exon 1 of the igf1 gene. This suppression required a functional androgen receptor (AR) and was independent of upstream Smad and Runx response elements. DHT also inhibited TGF-β induced IGF-I promoter activity but did not affect TGF-β's influence on DNA or collagen synthesis. Additionally, DHT differentially regulated other TGF-β activities, such as enhancing Smad dependent gene promoter activity. These findings highlighted the complex interactions between DHT and bone growth regulators, suggesting potential complications from anabolic steroid use in DHT sensitive tissues.

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Induction of Transforming Growth Factor-Beta 1 by Androgen Is Mediated by Reactive Oxygen Species in Hair Follicle Dermal Papilla Cells

research Induction of Transforming Growth Factor-Beta 1 by Androgen Is Mediated by Reactive Oxygen Species in Hair Follicle Dermal Papilla Cells

56 citations, September 2013 in “Journal of Biochemistry and Molecular Biology”

Androgens increase a growth factor in hair cells by creating reactive oxygen species, and antioxidants might help treat hair loss.

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community SCUBE3 and GT20029 could be the closet thing to a cure: Hair Follicle Regeneration and Protection Against DHT

in Research/Science 14 upvotes 1 year ago

SCUBE3 and GT20029 are potential treatments for hair loss, with SCUBE3 stimulating hair growth and GT20029 protecting against DHT. A combined approach using SCUBE3, finasteride or dutasteride, and later GT20029 could provide a comprehensive treatment for androgenetic alopecia.

community Is this broscience? From More Plates, More Dates

in Research/Science 22 upvotes 7 months ago

The conversation discusses whether finasteride's reduction of DHT and increase in scalp testosterone contribute to hair follicle miniaturization. Some participants argue testosterone does not cause miniaturization, while others suggest that even with reduced DHT, other androgens like testosterone may still contribute to hair loss.

community UPDATE: The theory that explains everything. Please help me make this big!

in Research/Science 443 upvotes 3 years ago

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.

community My Theory Regarding a Cause and Cure for Androgenetic Alopecia

in Treatment 96 upvotes 4 years ago

Hair loss theory suggests imbalance between Vitamin D Receptor (VDR) and Androgen Receptor (AR) activation. Proposed treatment includes upregulating VDR, downregulating AR, and improving mitochondrial health.

community One year anti androgen update CROWN

in Finasteride/Dutasteride 337 upvotes 1 year ago

User used Finasteride, Dutasteride, and Minoxidil for one year to treat hair loss. They discussed possibly trying RU58841 or pyrilutamide in the future.

community NMN Promotes Cell Proliferation and Hair Growth by Reducing Oxidative Stress

in Research/Science 14 upvotes 3 months ago

NMN shows promise in promoting hair growth by reducing oxidative stress and weakening androgens. It may be a beneficial addition to hair loss treatments like Minoxidil and Finasteride.