Complex Extract of Polygonatum Sibiricum and Nelumbinis Semen Improves Menopause Symptoms via Regulation of Estrogen Receptor Beta in an Ovariectomized Rat Model

The research investigated the effects of a complex extract of Polygonatum sibiricum (PS) and Nelumbinis semen (NS) on menopause symptoms in ovariectomized rat models. The extract was found to improve menopause symptoms by increasing estrogen receptor beta (ERβ) without affecting estrogen receptor alpha (ERα), reducing the risk of side effects like endometrial hyperplasia. It also improved vaginal dryness, depression symptoms, blood lipid metabolism, and bone loss. The extract did not alter 17β-estradiol and progesterone levels in the blood serum, indicating no risk of direct hormone regulation. The study suggests that the complex extract of PS and NS could be a new treatment for menopause with fewer side effects than conventional treatments like Hormone Replacement Therapy (HRT). The study involved 6-10 rats in each group.