Intrinsic Versus Extrinsic Aging: A Histopathological, Morphometric, and Immunohistochemical Study of Estrogen Receptor β and Androgen Receptor
January 2016
in “
Skin Pharmacology and Physiology
”
TLDR The study concluded that both estrogen and androgen receptors, which decrease with age, are linked to skin aging and may be hormonally regulated.
The study analyzed the expression of estrogen receptor β (ERβ) and androgen receptor (AR) in the skin of 60 subjects to understand their role in skin aging. It was found that both receptors were more highly expressed in sun-protected skin compared to sun-unprotected skin across all age groups. ERβ expression was highest in individuals aged 20-35 years and decreased with age, while AR expression also showed a negative correlation with age. The study concluded that the decline in ERβ and AR is associated with both intrinsic and extrinsic aging, and that ERβ is correlated with epidermal thickness. No significant differences in receptor expression were observed between genders or between premenopausal and postmenopausal females. The findings suggest a hormonal regulation of skin aging and indicate a need for further research to understand the clinical significance of these receptors in the aging process.
