TLDR Hormonal interactions, especially involving DHT and estrogen, play a key role in BPH development and treatment.
The document reviewed the roles of estrogen and androgen signaling in the pathogenesis of benign prostatic hyperplasia (BPH), emphasizing the importance of dihydrotestosterone (DHT) and the differential expression of steroid 5 alpha-reductase isozymes in normal and hyperplastic prostate tissues. It discussed the therapeutic potential of inhibitors like finasteride and dutasteride in reducing DHT levels. Additionally, it examined how estrogens modulate androgen receptor expression and impact cell proliferation, highlighting the complexity of hormonal interactions in BPH and the potential for targeted therapies. The research also noted the significant role of estrogen signaling, particularly through ER-beta, in BPH development, independent of androgen signaling.
408 citations,
May 2004 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” Dutasteride more effectively lowers DHT levels in men with enlarged prostates than finasteride.
3 citations,
January 2001 in “Cambridge University Press eBooks” Finasteride effectively treats hair loss and enlarged prostate in men, with mild side effects.
101 citations,
April 1994 in “Baillière's clinical endocrinology and metabolism” 5α-reductase is essential for male sexual development and its inhibitors have potential in treating various conditions related to hormone action.
21 citations,
January 2020 in “General and Comparative Endocrinology” Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.
47 citations,
September 2016 in “Reviews in endocrine and metabolic disorders” The skin's ability to produce hormones is linked to various skin conditions, and better understanding this process could lead to new treatments.
10 citations,
June 2010 in “Expert Opinion on Drug Metabolism & Toxicology” Finasteride reduces prostate cancer risk but may increase high-grade cancer chances.
4 citations,
November 2022 in “Frontiers in endocrinology” The enzyme 5α-reductase type 1 is important for blood vessel development and fertility in the uterus.
May 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” The enzyme 5α-reductase is important for proper blood vessel development during the fertility-related transformation of the uterus lining.
