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    Glossary Epigenetic Changes

    modifications in gene expression without altering the DNA sequence

    Epigenetic changes refer to modifications in gene expression that do not involve alterations to the underlying DNA sequence. These changes can be influenced by various factors such as environment, lifestyle, and disease, and they can affect how genes are turned on or off. Common mechanisms include DNA methylation and histone modification, which can have significant impacts on biological processes and conditions, including hair growth and alopecia.

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    1. 803 Taxane chemotherapy induces epigenetic changes and premature senescence in human scalp hair follicles Journal of Investigative Dermatology · 2024
    2. Promoter Methylation Changes in KRT17: A Novel Epigenetic Marker for Wool Production in Angora Rabbit International journal of molecular sciences · 2022 · 2 citations
    3. Identifying molecular targets for reverse aging using integrated network analysis of transcriptomic and epigenomic changes during aging Scientific Reports · 2021 · 12 citations
    4. 1435 Dynamic morphogen-p63 chromatin interactions that guide epigenetic changes and p63 activity in surface ectoderm commitment Journal of Investigative Dermatology · 2018
    5. Do Changes in Chromosomes Cause Aging? Cell · 1996 · 50 citations
    6. Epigenetic control of skin and hair regeneration after wounding Experimental Dermatology · 2014 · 36 citations
    7. The Post-finasteride Syndrome: Clinical Manifestation of Drug-Induced Epigenetics Due to Endocrine Disruption Current Sexual Health Reports · 2018 · 8 citations
    8. Epigenetic regulations on skin wound healing: implications from current researches. PubMed · 2015 · 5 citations
    9. Epigenetic and transcriptional profiling of secondary hair follicle stem cells during cashmere growth Scientific Data · 2026
    10. Hair loss due to pollution, micro metabolic dysfunction, epigenetics and role of nutrients Brazilian Journal of Hair Health · 2024
    11. Trazodone by epigenetic mechanism can reverse the post finasteride syndrome Magna Scientia Advanced Research and Reviews · 2023
    12. Finasteride Induces Epigenetic Alteration of TMPRss2 Gene Expression: A Potential role in Severe Acute Respiratory Syndrome-Corona Virus-2 Inhibition 2023
    13. Epigenetic and Environmental Regulation of Skin Appendage Regeneration 2015
    14. Integrated Analysis of Methylome and Transcriptome Changes Reveals the Underlying Regulatory Signatures Driving Curly Wool Transformation in Chinese Zhongwei Goats Frontiers in Genetics · 2020 · 39 citations
    15. Maternal nutrition at conception modulates DNA methylation of human metastable epialleles Nature communications · 2014 · 432 citations
    16. Tregs: Where We Are and What Comes Next? Frontiers in Immunology · 2017 · 130 citations
    17. Exploring the Drug Repurposing Versatility of Valproic Acid as a Multifunctional Regulator of Innate and Adaptive Immune Cells Journal of immunology research · 2019 · 47 citations
    18. Stem cells and aberrant signaling of molecular systems in skin aging Ageing Research Reviews · 2014 · 25 citations
    19. DNA Methyltransferases in Malar Melasma and Their Modification by Sunscreen in Combination with 4% Niacinamide, 0.05% Retinoic Acid, or Placebo BioMed Research International · 2019 · 20 citations
    20. Deciphering principles of morphogenesis from temporal and spatial patterns on the integument Developmental Dynamics · 2015 · 19 citations
    21. Modulation of genomic and postgenomic alterations in noncancer diseases and critical periods of life Mutation research · 2008 · 9 citations
    22. Glycolytic Dysfunction in Granulosa Cells and Its Contribution to Metabolic Dysfunction in Polycystic Ovary Syndrome Drug Design Development and Therapy · 2025 · 3 citations
    23. Role of Environmental Factors and Gonadotoxin Exposure in Unexplained Male Infertility Springer eBooks · 2015 · 2 citations
    24. Letter to the Editor: “Characteristics of Men Who Report Persistent Sexual Symptoms After Finasteride Use for Hair Loss” The Journal of Clinical Endocrinology and Metabolism · 2017 · 1 citations
    25. A Comprehensive Review on Alopecia: Mechanisms, Classification, and Therapeutic Strategies Zenodo (CERN European Organization for Nuclear Research) · 2026
    26. A Comprehensive Review on Alopecia: Mechanisms, Classification, and Therapeutic Strategies Zenodo (CERN European Organization for Nuclear Research) · 2026
    27. Environmental Modulation of JAK3-Mediated Immune Dysregulation in Alopecia Areata Scholarly Commons (Embry–Riddle Aeronautical University) · 2025
    28. Table 1_Integrated single-cell chromatin and transcriptomic analyses of peripheral immune cells in patients with alopecia areata.docx Figshare · 2025
    29. Advances in the Molecular Pathogenesis and Targeted Therapy of Psoriasis Galen Medical Journal · 2025
    30. 254 WITHDRAWN Journal of Investigative Dermatology · 2017