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This review highlights that both human-derived and plant-derived exosomes show anti-inflammatory and antioxidant properties, with human exosomes being better for targeted medicinal treatments due to their ability to transport healing drugs, while plant exosomes are more scalable and cost-effective for cosmetic applications.

This review suggests that although hydrolyzed collagen peptides with certain supplements may improve skin elasticity and joint function, evidence for collagen's anti-aging and regenerative benefits remains inconsistent.

This study synthesizes knowledge of how dendritic cell signals, epithelial integrins, and fibroblast activity converge on TGF-β1 to maintain or disrupt skin healing, contrasting normal and fibrotic scar formation and suggesting possible integrin and immune-targeted treatments for skin fibrosis.

This paper reviews the benefits of using silk proteins as natural ingredients in cosmetics, highlighting their potential for improving skin and hair health due to properties like antimicrobial activity, UV resistance, and enhanced moisture absorption.

This study found that IL-9 influences the behavior of human primary keratinocytes by promoting motility while reducing invasion potential through a novel mechanism independent of matrix-metalloproteinases.

This review discusses the evolving understanding of epithelial stem cells, noting how new models challenge old assumptions and suggesting multiple stem cell populations contribute differently to skin and hair follicle regeneration.

In this study using a rat full-thickness burn model, the amnion bilayer dressing showed better healing and skin recovery than the standard protocol, including quicker complete healing and restored skin appendages.

In this study, Far2-/- mice were observed to develop focal alopecia with altered sebaceous gland morphology and lower skin lipid levels compared to wildtype mice.

This review provides an overview of composite scaffold materials for skin that mimic natural dermal tissue, and highlights their potential in treating chronic wounds like diabetic foot by promoting cellular growth.

In this study, CD109 overexpression in transgenic mice led to reduced inflammation and improved collagen organization during wound healing without affecting wound closure.

This study found that electrospun short fibrous sponges effectively mimic the 3D extracellular matrix, promoting tissue regeneration, angiogenesis, and wound healing in diabetic rats better than 2D fiber membranes.

This article reviews the roles and mechanisms of stem and progenitor cell migration in adult organs for tissue homeostasis and regenerative medicine, but reports no new experimental results.

This review discusses surface engineered metal-organic frameworks for wound healing and reports no new clinical results; it highlights their potential as antibacterial agents, therapeutic delivery systems, and wound dressings.

This review discusses the role of extracellular vesicles as therapeutic agents for wound healing and highlights the need for further research into their clinical applications.

This research found that LSE transplantation positively affects wound healing by promoting granulation tissue growth and minimizing cosmetic defects in ischemic non-healing wounds during preclinical studies. Additionally, the proposed smoothing coefficient helps assess the degree of wound bed filling with developing tissue.

This study demonstrates that using transwell culture significantly influences hair follicle formation in skin models, potentially improving dermatology and skin research methodologies.

This study developed a bilayer bionic skin scaffold that mimics the skin's structure to resist microbial invasion and enhance wound healing, with in vivo animal studies showing improved collagen deposition, neovascularization, and hair follicle formation.

In this review, the authors reported that exosomal miRNA-based therapies showed promising therapeutic effects on nine skin diseases in animal models, with enhanced outcomes observed when using miRNA-overexpressing exosomes compared to natural ones; however, no comparisons to standard treatments were available.

This review highlights that skin organoids, advanced three-dimensional models mimicking human skin, are emerging as effective alternatives to traditional culture models and human skin, overcoming limitations of two-dimensional systems and ethical concerns, and are being increasingly used in areas like developmental biology and disease modeling.

This study found that ECMs from papillary and dermal papilla fibroblasts support normal basement membrane formation, suggesting potential improvements for therapeutic biomaterials in skin engineering.

This review covers advancements in skin repair and rejuvenation technologies, highlighting potential benefits of stem cell therapy, bioengineered skin substitutes, PRP, exosome therapies, and gene editing for conditions such as chronic wounds and genetic disorders, though challenges in accessibility, safety, and long-term effectiveness remain.

This study demonstrated that implanting μm-scale full-thickness columns of human skin tissue into immunodeficient mice restored key features of normal human skin, suggesting potential for human wound repair with minimal donor site morbidity.

This review examines the major biomaterials used in skin wound healing and evaluates experimental therapies but reports no new research findings.

In this study, the researchers developed a biomimetic multilayer composite scaffold combining a decellularized amniotic membrane, fibroblast-laden collagen gel, and epidermal stem cells, which healed full-thickness skin wounds more quickly and effectively by regenerating hair follicles without scarring compared to Moropicin ointment.

This study introduces a spherical skin model that effectively mimics key features of human skin, offering a scalable and rapid alternative for non-animal dermatological and cosmetic testing.

In this study, researchers developed self-assembled skin models derived from hair follicle cells, offering an ethical and reliable alternative to animal testing and bovine collagen in dermatological research by providing functional dermal and epidermal layers for substance evaluation.

This study found that human hair follicle dermal papilla cells cultivated as 3D spheroids in hexanoyl glycol chitosan-coated dishes formed hair-like structures, with minoxidil enhancing growth, and successfully integrated into artificial skin models, suggesting advancements for hair loss treatments and skin restoration therapies.

This review discusses how advancements in biomaterial engineering and 3D bioprinting are transforming skin wound-healing therapies, highlighting innovations in bioinks and the evolving global market potential of these technologies for developing next-generation skin substitutes.

In this review, it is discussed how mesenchymal stem cell aggregation plays a crucial role in organ development and has potential applications in organ regeneration through tissue engineering.

This review discusses skin tissue engineering and highlights the potential role of microRNAs in improving bioengineered skin equivalents, concluding that further exploration of microRNA targets could address unmet clinical needs.