The Model of an Ischemic Non-Healing Wound: Regeneration After Transplantation of a Living Skin Equivalent

October 2023 in “ Sovremennye tehnologii v medicine ”

Elena I. Morgun, К. К. Сухинич, O. S. Rogovaya, Е. A. Vorotelyak

Living Skin Equivalent ischemic non-healing wounds angiogenesis inflammatory cell infiltration tissue formation wound margin condition granulation tissue growth tissue remodeling

TLDR Living Skin Equivalent transplantation helps heal ischemic non-healing wounds.

The study investigates the effectiveness of Living Skin Equivalent (LSE) transplantation in treating ischemic non-healing wounds using histology and immunohistochemistry. It examines the impact on inflammatory cell infiltration, tissue formation, wound margin condition, and angiogenesis. A new smoothing coefficient is introduced to evaluate tissue remodeling, with high values indicating enhanced granulation tissue growth and reduced cosmetic defects. The findings suggest that the proposed ischemic non-healing wound model is suitable for preclinical studies of BCP, highlighting its potential in regenerative processes.

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The Model of an Ischemic Non-Healing Wound: Regeneration After Transplantation of a Living Skin Equivalent

Research cited in this study

research Macrophages Induce AKT/β-Catenin-Dependent Lgr5+ Stem Cell Activation and Hair Follicle Regeneration Through TNF

research Principles and Mechanisms of Regeneration in the Mouse Model for Wound-Induced Hair Follicle Neogenesis

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