Histological and Immunohistochemical Studies of Excisional Wounds in Rats: The Role of Hair Follicles in Wound Healing

    January 2000 in “ Durham e-Theses (Durham University) ”
    Raymond Debono
    TLDR Hair follicles help wounds heal faster, especially in active growth phase skin.
    The study investigated the role of hair follicles in wound healing using a PVG rat model, focusing on differences between anagen and telogen skin. It was found that anagen skin had significantly smaller wound diameters than telogen skin at 7 and 8 days post-wounding. The epithelial basement membrane began regenerating centrally and peripherally in the wound epithelium. The dermal sheath of hair follicles merged with the wound fibroblast network, and alpha smooth muscle actin staining indicated dermal sheath cell migration into the wound. These findings suggested potential improvements in living skin equivalents and supported the use of the scalp as a donor site for split thickness skin grafts.
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