Amnion Bilayer for Dressing and Graft Replacement for Delayed Grafting of Full-Thickness Burns: A Study in a Rat Model

In this study, researchers investigated the effectiveness of an amnion bilayer (AB) as a dressing and graft for full-thickness burns in a rat model. The study involved 12 Sprague-Dawley rats divided into two groups, with one group receiving the AB treatment and the other following the National Hospital of Indonesia (NHI) protocol. The results showed that the AB group experienced complete healing with the regeneration of skin appendages, such as hair follicles and adipose tissue, within 28 days. In contrast, the NHI group exhibited a denatured matrix and lacked skin appendages in the inflamed area. The AB group also demonstrated increased angiogenesis and less scarring compared to the NHI group, indicating that the amnion bilayer could potentially accelerate healing and improve outcomes in full-thickness burn treatment.