Extracellular Matrix-Based Combination Scaffold for Guided Regeneration of Large-Area Full-Thickness Rabbit Burn Wounds Upon a Single Application

    November 2021 in “ Journal of biomedical materials research. Part B, Applied biomaterials ”
    Rashmi Ramakrishnan, Harikrishnan Vijayakumar Sreelatha, Arya Anil, A Sabareeswaran, Lissy K. Krishnan
    TLDR AMFIBHA scaffold significantly healed large full-thickness burn wounds in rabbits and restored skin's mechanical properties.
    The study evaluates the wound healing capabilities of a novel extracellular matrix-based skin substitute, AMFIBHA, composed of amniotic membrane, fibrin, and hyaluronic acid. Tested on large-area third-degree rabbit burn wounds, AMFIBHA demonstrated effective hemostasis, suture-less application, and degradation in wet wounds to release biologically active molecules that guide cell migration, proliferation, and regeneration. After 28 days, the product showed significant epithelial-dermal regeneration with angiogenesis, and by 56 days, the treated tissue regained mechanical properties comparable to native skin. The results suggest that AMFIBHA has promising translational value as an off-the-shelf product for clinical use in wound care.
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