Enhanced Skin Regeneration Using a Novel Amniotic-Derived Tissue Graft

In 2017, a study was conducted to compare the effectiveness of different types of amniotic-derived tissue grafts in wound healing. The study used a full-thickness rat wound model and treated the wounds with either dehydrated amnion/chorion (dHACM) grafts, dHACM meshed grafts, hypothermically stored amniotic membrane (HSAM) grafts, or left the wound ungrafted. The results showed that all amniotic-derived tissue grafts improved healing over ungrafted wounds, with more normal-appearing dermal matrix architecture, epidermal structure, and maturity. However, the HSAM grafts promoted greater tissue regeneration than the dHACM meshed grafts, as measured by the presence of basket-weave collagen matrix and formation of follicles and glands. The study concluded that the processing of amniotic tissues significantly affects the quality of wound healing.