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This review discusses recent advancements in biomaterial scaffolds for wound healing, focusing on their roles and potential in skin regeneration, but it does not present new clinical results.

In this study, the researchers developed a biomimetic multilayer composite scaffold combining a decellularized amniotic membrane, fibroblast-laden collagen gel, and epidermal stem cells, which healed full-thickness skin wounds more quickly and effectively by regenerating hair follicles without scarring compared to Moropicin ointment.

This study reports that a collagen scaffold with p-Coumaric acid showed promising wound-healing effects in diabetic wound models by enhancing tissue regeneration and balancing collagen turnover.

This perspective reviews enzyme-instructed self-assembly (EISA) as a conceptual framework for supramolecular chemical biology, emphasizing its innovative role in developing adaptive biomaterials and synthetic cellular machines without providing new experimental results.

This review discusses recent advances in developmental tissue engineering for regenerating ectodermal appendages like teeth and glands, emphasizing biomaterial selection and cell culture strategies, but reports no new experimental results.

Early-stage skin substitutes improve wound healing and skin structure.

This study developed HA-gel-dex hydrogels with enhanced ECM-like properties and functionality, showing promise for 3D bioprinting, tissue repair, and as wound dressings due to improved cell interaction, cytocompatibility, antimicrobial synergy, and wound healing in mice compared to traditional ECM bio-inks.

This study developed a novel hydrogel combining Chlorella extracellular polysaccharide–selenium nanoparticles (EPS-SeNPs) with biocompatible components, which demonstrated strong antibacterial and anti-inflammatory effects, significantly accelerating wound healing in an infected rat model, and enabling pH-based monitoring of healing.

This review outlines strategies for regulating macrophage response using bioactive materials to enhance wound healing, focusing on extracellular matrix-based scaffolds and nanofibrous composites, but reports no new clinical results.

This study found that mouse embryoid bodies adhered quickly and differentiated efficiently into cardiomyocytes on negatively charged poly(sodium p-styrene sulfonate) hydrogels, similar to their behavior on gelatin-coated polystyrene.

This review discusses recent advances in the development of electrospun pectin nanofibers for biomedical applications, highlighting strategies to improve their mechanical properties and biological functions and addressing challenges like material variability and regulatory issues.

This study found that chitosan nanofibrillar scaffolds accelerated skin wound healing in mice by enhancing cell adhesion, proliferation, and regeneration of epidermis and dermis compared to other forms.

This study found that a new SIS-PEG sponge promoted rapid skin defect healing in mice and showed potential for reconstructing reconstituted skin with regenerated hair.

This review discusses the various components essential for successful tissue engineering, such as cell sources, modification methods, and supportive matrices, and highlights the need for functional synergy without reporting new experimental results.

This study developed multifunctional nanofiber wound dressings that significantly reduced bacteria and promoted healing in a mouse wound model by incorporating antibacterial and growth-promoting agents.

In this study, researchers developed an axolotl skin-derived extracellular matrix scaffold that enhanced wound healing in mice by promoting skin regeneration and reducing fibrosis, offering potential as a regenerative biomaterial for clinical use.

This study found that applying both dehydrothermal treatment and carbodiimide crosslinking improved the mechanical properties of porcine acellular dermal matrix scaffolds without added cytotoxicity, suggesting potential applications in tissue engineering.

This study developed a directional pressure-pump hydrogel delivery platform that enhances wound healing in diabetic mechanically dynamic wounds by targeting antibacterial agents and nanozymes directly to the lesion site, disrupting biofilms, mitigating tissue damage, and supporting proper skin closure and vascular remodeling in animal models.

The patches could quickly deliver epilepsy treatment and reduce seizures.

This study reported that a composite hydrogel made with Chlorella-derived extracellular polysaccharide–selenium nanoparticles showed strong antibacterial and anti-inflammatory effects in vitro and significantly accelerated wound healing in vivo, offering potential for managing infected wounds and monitoring healing progression.

The demineralized bone matrix scaffold is better for cell attachment than the mineralized bone allograft.

The researchers reported that sulfated chitosan-containing sponges can modulate macrophage activity in diabetic wounds, reducing inflammation and promoting angiogenesis and tissue regeneration, which may enhance wound healing outcomes.

This study developed a double-network hydrogel using polyacrylamide and catechol-chitosan to enhance mechanical properties and promote drug release, aiding in inflammation regulation and wound healing for chronic wounds with challenging microenvironments.

In this study, poly (ɛ-caprolactone)–chitosan–poly (vinyl alcohol) nanofibrous scaffolds used on canine skin wound models were found to significantly accelerate healing rates of excision and burn wounds, without inducing immunogenic reactions.

This study found that heart-inspired hollow hydrogel-based scaffolds enhanced regenerative capability in osteoporotic bone defects and increased cell number when using a mechanical-assisted post-bioprinting strategy.

This study reports that a new artificial skin system using multi-layered hydrogels can promote scarless wound healing and regenerate appendages like hair follicles without cell transplantation.

Chitosan/LiCl composite scaffolds help heal deep skin wounds better.

This study observed that DMAP scaffolds in a full-thickness wound model promote dermal appendage regeneration by activating humoral immunity, specifically through B cell activation and antibody production, even when adaptive immune cells' infiltration is restricted.

The hydrogel helps heal seawater-immersed wounds by reducing infection and inflammation.