Poly (ɛ-Caprolactone)–Chitosan–Poly (Vinyl Alcohol) Nanofibrous Scaffolds for Skin Excisional and Burn Wounds in a Canine Model

    January 2018 in “ IET Nanobiotechnology ”
    Adeleh Gholipour‐Kanani, Monireh Mohsenzadegan, Mohammadreza Fayyazi, S. Hajir Bahrami, Alí Samadikuchaksaraei
    TLDR The scaffolds significantly sped up wound healing in dogs and were safe.
    The study demonstrated that poly (ɛ‐caprolactone)–chitosan–poly (vinyl alcohol) (PCL: Cs: PVA) nanofibrous scaffolds significantly accelerated the healing of skin excisional and burn wounds in a canine model involving 5 dogs. The scaffolds promoted better wound healing, with enhanced epidermal and dermal regeneration, including new gland formation, and increased collagen regeneration by attracting more fibroblasts. The scaffolds were also non-immunogenic, indicating their safety. These findings suggested that PCL: Cs: PVA nanofibrous scaffolds could be promising materials for wound healing applications.
    Discuss this study in the Community →