Poly (ɛ-Caprolactone)–Chitosan–Poly (Vinyl Alcohol) Nanofibrous Scaffolds for Skin Excisional and Burn Wounds in a Canine Model
January 2018
in “
IET Nanobiotechnology
”
TLDR The scaffolds significantly sped up wound healing in dogs and were safe.
The study evaluated poly (ɛ‐caprolactone)–chitosan–poly (vinyl alcohol) nanofibrous scaffolds for healing skin excisional and burn wounds in five large, mixed-breed male dogs. The scaffolds showed promising results in promoting wound healing, with enhanced epidermal and dermal regeneration, including hair follicles and glands formation. After 90 days, scaffold-treated wounds exhibited more advanced healing compared to untreated controls. The scaffolds demonstrated favorable mechanical and biological properties, were not immunogenic, and promoted complete epithelialization and collagen regeneration. These findings suggested the potential of these scaffolds for further development in wound care applications and clinical trials.
