Composite Hydrogel Based on Green Chlorella Polysaccharide–Selenium Nanoparticles for Simultaneous Wound Treatment and pH Monitoring

The study presents a novel composite hydrogel made from Chlorella extracellular polysaccharide–selenium nanoparticles (EPS-SeNPs) for wound treatment and pH monitoring. The hydrogel, cross-linked by oxidized sodium alginate and gelatin, demonstrated strong antibacterial and anti-inflammatory properties, with a 99% antibacterial rate and significant free radical clearance abilities. In vivo experiments on SD rats showed that the hydrogel accelerated wound healing, promoted new epidermis and hair follicle growth, and reduced inflammation. This innovative approach could enhance clinical management of infected wounds while allowing for simultaneous monitoring of the healing process.