Double Network Physical Crosslinked Hydrogel for Healing Skin Wounds: New Formulation Based on Polysaccharides and Zn2+

    August 2023 in “ International Journal of Molecular Sciences ”
    Shenghao Cui, Faming Yang, Dingyi Yu, Chao Shi, Di Zhao, Liqi Chen, Jingdi Chen
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    TLDR The new hydrogel with zinc and polysaccharides improves wound healing and has antibacterial properties.
    The document presents a study on a new formulation of a double network hydrogel, based on marine polysaccharides (sodium alginate and chitosan) and Zn2+ ions, for healing skin wounds. The hydrogel's structure consists of two networks, one formed by electrostatic interaction between sodium alginate and chitosan, and the second formed by ionic cross-linking between sodium alginate and Zn2+ ions. The addition of Zn2+ ions enhances the hydrogel's mechanical properties, antibacterial ability, and antioxidant activity. The hydrogel demonstrated strong antibacterial properties against E. coli and S. aureus, and was found to be non-toxic to HaCaT cells. In vivo wound healing experiments showed superior wound healing in the Zn2+-containing groups compared to the blank group. The hydrogel also promoted hair follicle regeneration, indicating its potential as a wound dressing. The study does not mention the number of samples used in the experiments.
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