Composite Hydrogel Based on Green Chlorella Polysaccharide–Selenium Nanoparticles for Simultaneous Wound Treatment and pH Monitoring

This study introduces a novel composite hydrogel made from Chlorella extracellular polysaccharide–selenium nanoparticles (EPS-SeNPs) and a biocompatible hydrogel matrix, designed for wound treatment and pH monitoring. The hydrogel demonstrated strong antibacterial (99% rate) and anti-inflammatory properties, effectively inhibiting pathogen growth and promoting wound healing. In vivo experiments on SD rats showed accelerated wound healing, new epidermis formation, and hair follicle growth. The hydrogel also allows for pH monitoring, indirectly predicting the healing process, offering a promising approach for clinical management of infected wounds.