177 citations
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April 2008 in “Biomedical Materials” This study found that scaffolds made from human hair proteins supported better cell growth and interactions than control surfaces, indicating potential use in tissue engineering.
9 citations
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February 2020 in “Materials Express” In a study on female SD rats, the authors found that RADA16-1 short-peptide nano-fiber gel scaffolds improved burn wound healing, hair follicle growth, hair growth length, and expression of bFGF and EGF compared to a NaCl control.
31 citations
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July 2023 in “Foods” This overview outlines the latest advancements and challenges in developing three-dimensional scaffolds for biomanufacturing cultured meat, focusing on organizing muscle stem cells to better mimic the structure of traditional meat. Results are not reported in the abstract.
1 citations
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March 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” In this study, the researchers reported that using a biodegradable ECM scaffold for large-area wound regeneration accelerated wound coverage and improved hair follicle neogenesis by activating the adaptive immune system.
114 citations
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November 2022 in “Biomedicine & Pharmacotherapy” This review discusses current wound management strategies and examines electrospun nanofibers with biological macromolecules for their potential in tissue engineering and drug delivery, but reports no new clinical results.
216 citations
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February 2022 in “Nanomaterials” This review discusses the potential of electrospun gelatin-based nanofiber dressings for wound healing and skin regeneration, detailing their properties, enhanced functionalities through crosslinking and bioactive components, and their application in treating challenging wound types like burns and diabetic wounds.
11 citations
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January 2024 in “Regenerative Biomaterials” This research reported that a newly developed dually crosslinked gelatin-alginate-based hydrogel scaffold enhances mechanical strength, promotes corneal tissue regeneration, and reduces scarring in rabbit models, suggesting potential applications in corneal tissue engineering.
14 citations
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March 2021 in “Regenerative Biomaterials” This study found that incorporating cell-adhesive ligands into 3D peptide hydrogels supports the survival and osteogenic differentiation of human amniotic mesenchymal stem cells.
30 citations
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September 2024 in “Pharmaceuticals” This research highlights the potential of using bioactive silk-based nanofiber dressings to improve the healing of diabetic wounds, suggesting that further studies are needed to refine these formulations and confirm their effectiveness in larger clinical trials.
November 2023 in “ACS Nano” In a mouse model of deep skin burns, this study found that a neuro-inspired biomimetic microreactor, when delivered through a hydrogel and activated by near-infrared light, significantly promoted functional skin regeneration, sensory recovery, and hair follicle formation.
15 citations
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January 2024 in “Journal of Materials Chemistry B” In this study, researchers developed an injectable silk fibroin-based hydrogel that enhances wound healing by protecting against oxidative stress and promoting tissue repair, outperforming commercial wound dressing Tegaderm™ in animal models.
1 citations
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March 2001 in “JOURNAL OF THE KYORIN MEDICAL SOCIETY” In this study, a collagen sponge with isogenic fibroblasts did not enhance skin graft survival or wound healing in rats, but it did promote re-epithelization, potentially inducing epithelial inclusion cysts.
In this study, exosome-loaded hydrogels derived from skin precursor cells significantly improved wound healing in diabetic rats by enhancing angiogenesis, reducing inflammation, and promoting tissue repair.
49 citations
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January 2017 in “Journal of Materials Chemistry B” This study developed a hydrogel from glycol chitosan and silica nanoparticles, which showed promise in wound healing by supporting microvessel and hair follicle growth in skin defects.
169 citations
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October 2020 in “Pharmaceutics” This review discusses recent advancements in formulating electrospun nanofibers as wound dressings, emphasizing their advantages in incorporating bioagents for improved healing, but reports no new clinical results.
January 2024 in “Journal of Tissue Engineering” In this study, researchers developed self-assembled skin models derived from hair follicle cells, offering an ethical and reliable alternative to animal testing and bovine collagen in dermatological research by providing functional dermal and epidermal layers for substance evaluation.
5 citations
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March 2025 in “Tissue Engineering and Regenerative Medicine” 10 citations
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August 2024 in “Chemical Engineering Journal” This study found that a microenvironment-responsive ATAN-Met hydrogel system improved infective diabetic wound healing by enhancing re-epithelialization, neurovascular and hair follicle regeneration, and exhibited antibacterial and immunoregulatory effects, activated beneficial pathways, and responded to glucose/ROS for drug release.
This review categorizes contractile hydrogels by their contraction mechanisms and explores their role in advanced wound management, emphasizing mechanical and biochemical signaling in healing, but also notes challenges like force transmission and clinical applicability.
This study suggests that human hair keratin-based gradient hydrogels incorporating silver ions may serve as promising dermal templates for wound healing, demonstrating favorable mechanical properties, cell interaction, and antibacterial activity.
January 2026 in “SSRN Electronic Journal” January 2026 in “SSRN Electronic Journal” January 2026 in “SSRN Electronic Journal” 1 citations
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June 2009 in “WakeSpace (Wake Forest University)” This study found that keratin biomaterials derived from human hair promoted significant motor function recovery and neuromuscular regeneration in animal models of peripheral nerve injuries.
48 citations
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April 2024 in “Nature Communications” This study demonstrated that a mechanical-assisted post-bioprinting strategy significantly increased cell numbers and enhanced regenerative capabilities in hollow hydrogel-based scaffolds for bone defect repair in vivo.
19 citations
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December 2022 in “Regenerative Biomaterials” This study found that gelatin–polycaprolactone/silk fibroin composite membranes with line micropatterns enhanced wound healing in rats by promoting cell alignment, angiogenesis, and increased α-SMA production.
12 citations
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September 2020 in “Stem cell research & therapy” This study concluded that early-stage tissue-engineered skin substitutes, developed using skin progenitor cells, had a better graft efficiency and supported hair follicle formation, which may improve wound healing outcomes.
July 2025 in “OPAL (Open@LaTrobe) (La Trobe University)” In this study, researchers developed a novel method using ultrasound stimulation and a hydrogel delivery system to enhance the regenerative effects of stem cell-derived extracellular vesicles on severe skin injuries, resulting in improved healing and hair follicle regeneration in a mouse model.
October 2025 in “Journal of Nanobiotechnology” This study reports that using a hydrogel-based therapy that dynamically regulates reactive oxygen species helps achieve skin regeneration in infected wounds, promoting organized dermal architecture with improved hair follicle and blood vessel formation, rather than scar formation.
July 2025 in “ACS Applied Materials & Interfaces” This study found that combining ultrasound with a GelMA hydrogel able to deliver mesenchymal stem cell-derived vesicles significantly improved wound healing in a mouse model by enhancing fibroblast activity, promoting re-epithelialization, and facilitating hair follicle regeneration, highlighting a novel approach to skin regeneration therapy.