Tracing Immune Cells Around Biomaterials With Spatial Anchors During Large-Scale Wound Regeneration

    March 2022 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Yang Yang, Chenyu Chu, Yi Man, Li Liu, Chenbing Wang, Yili Qu
    TLDR Biodegradable scaffolds help regenerate wounds and hair by activating the immune system.
    This study explored a method for large-area wound regeneration using biodegradable aligned extracellular matrix (ECM) scaffolds, which accelerated wound coverage and enhanced hair follicle neogenesis. The research utilized multimodal analysis to examine foreign body responses (FBR) around biomaterials, identifying cell heterogeneity through single-cell RNA sequencing. Spatial anchors revealed preferential recruitment of T cells around biomaterials, colocalized with hair follicle precursor cells. The study suggested that the adaptive immune system, activated by biomaterials, had a pro-regenerative effect on hair follicle neogenesis. Immunodeficient mice lacking mature T lymphocytes were unable to activate papillary fibroblasts or stimulate hair follicle regeneration, highlighting the therapeutic potential of the adaptive immune system in biomaterial applications.
    Discuss this study in the Community →

    Research cited in this study

    11 / 11 results

    Related Community Posts Join

    6 / 31 results

      community The Worst Hair Loss Condition You (MAY) have: LPP

      in Research/Science  43 upvotes 1 year ago
      Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

      community Best Treatment In The Pipeline?

      in Chat  15 upvotes 1 year ago
      New treatments for AGA are emerging, including pyrilutumide, gt0029, scube3, kx-826, and pp405. Verteporfin is mentioned as a promising option.

      community Has anyone else seen this encouraging verteporfin case study?

      in Progress Pictures  40 upvotes 1 year ago
      The conversation discusses the potential use of verteporfin for hair loss treatment, with one user mentioning their surgeon's interest in trying it and another noting its research status and clinical use as a YAP inhibitor. Some users debate the market size, availability of generics, and the optimism in the hair loss community regarding new treatments.

      community Tropoelastin injections + verteporfin?

      in Research/Science  12 upvotes 2 years ago
      The use of tropoelastin injections and verteporfin for hair transplant recipients to help regrow donor area hairs, as well as research done on tropoelastin injections restoring elastin in scarred heart tissue and skin. There are discussions about why it is taking so long to get cosmetic mass produced tropoelastin injectables on the market.

      community DUPA, Non Responders and Connective Tissue Disorders

      in Research/Science  9 upvotes 5 months ago
      A 27-year-old male with diffuse hair loss, including the donor area, did not respond to finasteride, dutasteride, or minoxidil. He suspects his hair loss may be linked to a mild connective tissue disorder, possibly affecting the structural support of hair follicles, rather than being purely hormonal.

    Related Research

    10 / 10 results