Tracing Immune Cells Around Biomaterials With Spatial Anchors During Large-Scale Wound Regeneration

    March 2022 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Yang Yang, Chenyu Chu, Yi Man … Yili Qu

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary In this study, the researchers reported that using a biodegradable ECM scaffold for large-area wound regeneration accelerated wound coverage and improved hair follicle neogenesis by activating the adaptive immune system.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 11

    1. Dissecting the Microenvironment Around Biosynthetic Scaffolds in Murine Skin Wound Healing Science Advances · 2021
    2. Bacteria Induce Skin Regeneration via IL-1β Signaling Cell Host & Microbe · 2021
    3. Distinct Regulatory Programs Control the Latent Regenerative Potential of Dermal Fibroblasts During Wound Healing Cell stem cell · 2020
    4. Noncoding dsRNA Induces Retinoic Acid Synthesis to Stimulate Hair Follicle Regeneration via TLR3 Nature Communications · 2019
    5. Single-Cell Analysis Reveals Fibroblast Heterogeneity and Myeloid-Derived Adipocyte Progenitors in Murine Skin Wounds Nature Communications · 2019
    6. Dermal Blimp1 Acts Downstream of Epidermal TGFβ and Wnt/β-Catenin to Regulate Hair Follicle Formation and Growth Journal of Investigative Dermatology · 2017
    7. Macrophages Induce AKT/β-Catenin-Dependent Lgr5+ Stem Cell Activation and Hair Follicle Regeneration Through TNF Nature Communications · 2017
    8. Regeneration of Fat Cells from Myofibroblasts During Wound Healing Science · 2017
    9. Epidermal Notch1 Recruits RORγ+ Group 3 Innate Lymphoid Cells to Orchestrate Normal Skin Repair Nature Communications · 2016
    10. Distinct Fibroblast Lineages Determine Dermal Architecture in Skin Development and Repair Nature · 2013
    11. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007

    Related research 10

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    2. May the Best Wound WIHN: The Hallmarks of Wound-Induced Hair Neogenesis Current Opinion in Genetics & Development · 2021
    3. Wound-Induced Hair Neogenesis: A Novel Paradigm for Studying Regeneration and Aging Frontiers in Cell and Developmental Biology · 2020
    4. Wound-Induced Hair Follicle Neogenesis: A New Perspective on Hair Follicle Regeneration in Adult Mammals PubMed · 2020
    5. Hair Follicle Neogenesis in Adult Skin The Molecular Biology Society of Japan · 2018
    6. Inducing Hair Follicle Organogenesis With Defined Environmental Protein Factors Journal of Dermatological Science · 2016
    7. A Model System to Analyze the Ability of Human Keratinocytes to Form Hair Follicles Experimental Dermatology · 2014
    8. Do We Need Hair Follicle Stem Cells and Hair Follicle Neogenesis to Cure Common Hair Loss Disorders? Hair transplant forum international · 2008
    9. Regenerating Hair Follicles Science's STKE · 2007
    10. New Hair From Healing Wounds Nature · 2007