A Mechanical-Assisted Post-Bioprinting Strategy for Challenging Bone Defects Repair

    April 2024 in “ Nature Communications ”
    Jirong Yang, Zhigang Chen, Chongjian Gao, Juan Liu, Kaizheng Liu, Xiao Wang, Xiaoling Pan, Guocheng Wang, Hongxun Sang, Haobo Pan, Wenguang Liu, Changshun Ruan
    TLDR The new method improves bone repair by enhancing cell loading and stability in bioprinted scaffolds.
    The study introduces a mechanical-assisted post-bioprinting strategy using heart-inspired hollow hydrogel-based scaffolds (HHSs) to improve cell loading for tissue regeneration. This method addresses the challenges of cell damage and poor mechanical stability in bioprinted scaffolds. HHSs enable rapid, uniform, and precise cell loading within 4 seconds, achieving a 13-fold increase in cell number and allowing partitioned loading of two cell types. The approach demonstrates enhanced regenerative capability in repairing critical-sized segmental and osteoporotic bone defects in vivo, suggesting a promising advancement for cell-based regenerative therapy.
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