A Mechanical-Assisted Post-Bioprinting Strategy for Challenging Bone Defects Repair

    September 2023 in “ Research Square (Research Square) ”
    Changshun Ruan, Jirong Yang, Zhi‐Gang Chen, Chongjian Gao, Juan Liu, Kaizheng Liu, Xiao Wang, Xiaoling Pan, Guocheng Wang, Hongxun Sang, Haobo Pan, Wenguang Liu
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    Studysummary This study found that heart-inspired hollow hydrogel-based scaffolds enhanced regenerative capability in osteoporotic bone defects and increased cell number when using a mechanical-assisted post-bioprinting strategy.
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    The study introduces a mechanical-assisted post-bioprinting strategy using heart-inspired hollow hydrogel-based scaffolds (HHSs) to improve cell loading in bioprinting for tissue regeneration. This method addresses issues of cell damage and poor mechanical stability in bioprinted scaffolds by enabling rapid, uniform, and precise cell loading within 4 seconds, achieving a 13-fold increase in cell number and allowing partitioned loading of two cell types. The HHSs demonstrated enhanced regenerative capabilities in repairing critical-sized segmental and osteoporotic bone defects in vivo, suggesting this strategy as a promising approach for advancing cell-based regenerative therapies.
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