A Biopolymeric Scaffold Incorporated With p-Coumaric Acid Enhances Diabetic Wound Healing by Modulating MMP-9 and TGF-β3 Expression

March 2023 in “ Colloids and surfaces. B, Biointerfaces ”

Gopika Selvakumar, Lonchin Suguna

p-coumaric acid MMP-9 TGF-β3 fibroblast cells angiogenesis collagen deposition epidermis hair follicles biocompatible polymeric scaffold matrix metalloproteinase-9 transforming growth factor beta 3 new blood vessel formation skin layer biocompatible scaffold

TLDR A new wound dressing with p-Coumaric acid helps heal diabetic wounds faster by reducing inflammation and promoting skin repair.

The study developed a biocompatible polymeric scaffold enriched with p-coumaric acid (Col-OxP3-Ca) to enhance diabetic wound healing. The scaffold demonstrated 85% antioxidant activity, biocompatibility with fibroblast cells, and improved cell proliferation and migration. In diabetic rats, wounds treated with the scaffold healed within 21 days, showing well-developed epidermis, blood vessels, hair follicles, reduced inflammation, and balanced collagen deposition. The scaffold modulated the expression of TGF-β3 and MMP-9, promoting angiogenesis and tissue regeneration. This suggests that Col-OxP3-Ca could be an effective alternative for treating chronic wounds.

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