Hypoxia-Preconditioned ADSC Exosomes Encapsulated in a Multifunctional Dual-Network Hydrogel Promote the Healing and Functional Regeneration of Seawater-Immersed Wounds

    June 2025 in “ Chemical Engineering Journal ”
    Jie Li, Zishuo Wang, Wenjing Yang, Yongchao Zhou, Tao Fu, Yuhui Zhang, Xuelian Duan, Dong Liu, Lingtong Kong, Yan Shang, Yuchen Zhang, Xuhui Wang, Runze Gao, Cheng Zhong, Long Chen, Qian Liu, Shuogui Xu, Shuo Fang, Yuntong Zhang, Yang Xie, Yuntong Zhang, Yuntong Zhang, Yang Xie
    TLDR The hydrogel helps heal seawater-immersed wounds by reducing infection and inflammation.
    The study presents a novel multifunctional dual-network hydrogel, PODH IV@H-Exos, designed for treating seawater-immersed wounds. This hydrogel, composed of hyperbranched polylysine (HBPL), oxidized dextran (ODEX), polyvinyl alcohol (PVA), borax, and hypoxia-preconditioned adipose-derived stem cell exosomes (Hypo-ADSC-Exos), demonstrates excellent mechanical properties, microfluidity, and ease of application. It effectively adheres to wet surfaces and can be removed painlessly. In vitro and in vivo experiments show that the hydrogel significantly inhibits infections by V. vulnificus, P. aeruginosa, and other marine pathogens, while promoting high-quality wound healing by reducing inflammation. This innovative approach integrates anti-infection therapy with dynamic healing regulation, offering a promising solution for complex seawater-immersed wounds.
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