Injectable Dual-Crosslinked Poly(Oligo(Ethylene Glycol) Methacrylate) Hydrogels Inspired by Mussel Adhesion for Cutaneous Wound Healing and Functional Tissue Regeneration

October 2025 in “ Advanced Healthcare Materials ”

Gurpreet Randhawa, Meghan Kostashuk, Zhicheng Pan, Nils Nordstrom, Thomas Kalab, Erica Winterhelt, Todd Hoare

poly(oligo(ethylene glycol) methacrylate) hydrogels dopamine cutaneous wound healing tissue regeneration collagen deposition hair follicles sebaceous glands blood vessels PEG hydrogels skin healing wound healing skin regeneration

TLDR The hydrogels improve wound healing and tissue regeneration better than traditional treatments.

The study explores the development of injectable dual-crosslinked poly(oligo(ethylene glycol) methacrylate) hydrogels, inspired by mussel adhesion, for cutaneous wound healing and tissue regeneration. These hydrogels, functionalized with dopamine, exhibit strong adhesion, high cytocompatibility, and rapid gelation, making them suitable for acute dermal wounds. In vivo tests on mice demonstrated enhanced wound healing, with significant improvements in collagen deposition, reduced inflammation, and regeneration of skin structures such as hair follicles, sebaceous glands, and blood vessels. The hydrogels outperformed traditional treatments, highlighting their potential as effective wound healing materials.

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