Adipose Stem Cell-Derived Exosomes in the Treatment of Wound Healing in Preclinical Animal Models: A Meta-Analysis

January 2024 in “ Burns & Trauma ”

Jing-tao Wei, Ting He, Kuo Shen, Zhigang Xu, Juntao Han, Xue-kang Yang

adipose stem cell-derived exosomes ADSC-Exos wound healing neovascularization epithelization collagen fiber deposition scar formation

TLDR Adipose stem cell-derived exosomes greatly improve wound healing.

A meta-analysis of adipose stem cell-derived exosomes (ADSC-Exos) therapy in preclinical animal models demonstrated that ADSC-Exos significantly enhance wound healing by promoting neovascularization, improving epithelization and collagen fiber deposition, and reducing scar formation in both general and diabetic wounds. These findings suggest that ADSC-Exos hold substantial promise for advancing wound healing treatments in both research and clinical settings.

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research Human Adipose-Derived Mesenchymal Stem Cells-Derived Exosomes Encapsulated in Pluronic F127 Hydrogel Promote Wound Healing and Regeneration

148 citations , August 2022 in “Stem Cell Research & Therapy”

Encapsulated stem cell exosomes in hydrogel improve wound healing.

research Human Acellular Amniotic Membrane Incorporating Exosomes from Adipose-Derived Mesenchymal Stem Cells Promotes Diabetic Wound Healing

132 citations , April 2021 in “Stem Cell Research & Therapy”

A special membrane with cell particles helps heal diabetic wounds faster.