Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This review explores the evaluation and treatment of hirsutism, emphasizing a systematic approach to uncovering its causes and recommending combination therapies for effective management, but presents no new results.

This study found that specific genetic markers near the androgen receptor gene are significantly more common in men with male pattern baldness, suggesting a genetic component in its development.

This article discusses the role of androgens in metabolic and reproductive health and reports no new experimental results; the focus is on androgen receptor activation by testosterone and 5α-dihydrotestosterone.

This study found that finasteride may affect Ca 2+ signalling in human sperm by interacting with the PGE 1 -binding site, but its impact on fertilization requires further investigation.

This study reported that exosomes derived from human amniotic mesenchymal stem cells (hAMSC-exo) accelerated hair growth in androgenetic alopecia mice by enhancing signals between hair follicle cells and improving cellular environments, particularly protecting against dihydrotestosterone-induced damage via Wnt/β-catenin signaling.

In this study, female rats given high doses of testosterone showed decreased endometrial thickness and lower mRNA levels of components in the LIF signalling pathway, indicating that excessive testosterone may negatively impact endometrial receptivity and potentially affect fertility.

In this study, researchers developed a novel platform for discovering potential hair loss inhibitors by investigating the testosterone/dihydrotestosterone biosynthetic pathway and its regulation through biochemical mechanisms involving 17β-HSD and 3β-HSD, combined with medicinal plant extracts.

This review discusses androgen therapy in adolescents, detailing current practices and noting the limited use of commercially available testosterone or dihydrotestosterone formulations; no new results are reported.

In this study, researchers used an integrated in silico approach to demonstrate that Polygonum multiflorum combats androgenetic alopecia via anthraquinone emodin, which targets PI3K catalytic subunits differently from traditional antiandrogenic treatments, showing potential as a novel therapeutic strategy.

This review discusses the roles of androgens and androgen receptor in skin diseases like acne and hirsutism, and highlights the promise of antiandrogen drugs, reporting no new clinical findings.

This study found that bufotalinin, derived from Merremia peltata leaves, may enhance hair growth by acting as a potential androgen receptor antagonist in rabbits.

This study suggests that three mushroom-derived bioactive compounds, Zhankuic acid A, Sterenin M, and Melleolide K, may effectively inhibit SRD5A2 and stabilize its interaction, indicating potential for treating androgenic alopecia.

This study found that ginsenoside Rg4 enhanced hair-inductive properties of dermal papilla cells via the AKT/GSK3β/β-catenin pathway, suggesting its potential as a natural therapy for hair growth.

This study found that Ficus benghalensis leaf extracts reduced the activity of 5 α-reductase II and promoted hair growth in rabbits by elongating the hair follicle's anagen phase, suggesting potential for treating hair loss.

This study suggests that the anti-inflammation and anti-oxidation properties of Taohong Siwu decoction may be linked to its effects on androgenic alopecia through specific biological processes and pathways.

This review highlights various treatments for androgenetic alopecia that target its underlying pathophysiological mechanisms, reporting enhanced hair growth, especially when combining drugs, which shows improved outcomes over individual drug use alone.

This review discusses recent advances in stimuli-responsive nanoformulations for CRISPR-Cas9 delivery, highlighting their design rationales and potential biomedical applications, but reports no new experimental results.

This study found that androgenetic alopecia may be a predictor of metabolic syndrome, emphasizing the importance of screening patients with severe hair loss for related health risks.

This article discusses differences in hair loss among monozygotic female twins despite identical genetics and reports no new clinical findings.

This study suggests that hydroxytyrosol may influence inflammation and oxidative stress pathways in androgenetic alopecia, particularly through interaction with the PTGS2 gene, warranting further experimental validation.

This study reports the development of a prototype robotic hair transplant system capable of efficiently harvesting and implanting hair grafts, showing promising accuracy and performance in tests using a spherical scalp phantom.

This study developed a new crystallization method using solid solution formation to purify finasteride by effectively removing contamination with dihydrofinasteride.

This study identified seven new compounds from the plant Sansevieria trifasciata Prain and predicted that four of them may have better anti-alopecia activity than minoxidil through an in silico approach.

This review provides an analysis of the physiological and pathological aspects of polycystic ovary syndrome, emphasizing endocrine, metabolic, and inflammatory dimensions, but reports no new clinical results.

This review discusses the chemical composition, potential health benefits, and extraction methods of red ginseng oil, and reports no new clinical results but emphasizes safety and proposed molecular mechanisms.

This review discusses the role of gut steroids in communicating with the gut microbiota and their potential implications in treating gastrointestinal disorders and related brain conditions, suggesting new perspectives on steroid molecules as therapeutic agents.

This study found that the Qing Cuo Formula significantly reduced serum androgen and inflammatory cytokine levels in hamsters with damp-heat acne and identified potential molecular mechanisms and active compounds involved.

This research reports that copper-quercetin complexes show strong potential in antioxidation and cancer therapy, while their effects on specific cell death pathways warrant further investigation.

This study suggests that Hejie Shengfa Decoction may help treat alopecia areata by influencing immune and inflammatory pathways, regulating apoptosis, and enhancing the follicular microenvironment.

In this study, researchers found that fermented ginsenoside from kimchi-derived bacteria enhanced hair growth in a mouse model and increased hair cell proliferation by 25% in vitro, suggesting potential as a therapeutic candidate for promoting hair growth.