A Platform for Determining Medicinal Plants with Targeted 17β-Hydroxysteroid Dehydrogenase Modulation for Possible Hair Loss Prevention

    February 2024 in “ Cosmetics ”
    Suhyeon Park, Neha Kaushik, Geunjeong Lee … June-Hyun Kim
    Studysummary In this study, researchers developed a novel platform for discovering potential hair loss inhibitors by investigating the testosterone/dihydrotestosterone biosynthetic pathway and its regulation through biochemical mechanisms involving 17β-HSD and 3β-HSD, combined with medicinal plant extracts.
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    Research cited in this study 28

    1. Alleviation of Androgenetic Alopecia with Aqueous Paeonia Lactiflora and Poria Cocos Extract Intake Through Suppressing the Steroid Hormone and Inflammatory Pathway Pharmaceuticals · 2021
    2. Sulforaphane, L-Menthol, and Dexpanthenol as a Novel Active Cosmetic Ingredient Composition for Relieving Hair Loss Symptoms Cosmetics · 2021
    3. Survey of Use of Herbal and Home Remedies for Hair and Scalp Among Women in North West Saudi Arabia Dermatology Reports · 2020
    4. Epigallocatechin-3 Gallate Inhibits STAT-1/JAK2/IRF-1/HLA-DR/HLA-B and Reduces CD8 NKG2D Lymphocytes in Alopecia Areata Patients International journal of environmental research and public health/International journal of environmental research and public health · 2018
    5. An Open-Label Randomized Multicenter Study Assessing the Noninferiority of a Caffeine-Based Topical Liquid 0.2% Versus Minoxidil 5% Solution in Male Androgenetic Alopecia Skin Pharmacology and Physiology · 2017
    6. Epigallocatechin Gallate-Mediated Alteration of the MicroRNA Expression Profile in 5α-Dihydrotestosterone-Treated Human Dermal Papilla Cells Annals of Dermatology · 2016
    7. Combined Treatment with Oral Finasteride and Topical Minoxidil in Male Androgenetic Alopecia: A Randomized and Comparative Study in Chinese Patients Dermatologic Therapy · 2015
    8. Alopecia Areata Update Seminars in Cutaneous Medicine and Surgery · 2015
    9. Herbal Extracts Induce Dermal Papilla Cell Proliferation of Human Hair Follicles Annals of Dermatology · 2015
    10. Effect of Pumpkin Seed Oil on Hair Growth in Men with Androgenetic Alopecia: A Randomized, Double-Blind, Placebo-Controlled Trial Evidence-based Complementary and Alternative Medicine · 2014
    11. Hair Growth-Promoting Effect of Carthamus Tinctorius Floret Extract Phytotherapy Research · 2013
    12. Clinical Biochemistry of Dihydrotestosterone Annals of Clinical Biochemistry · 2013
    13. Promotion of Hair Growth by Rosmarinus Officinalis Leaf Extract Phytotherapy Research · 2012
    14. Evaluation of Efficacy and Safety of Finasteride 1 mg in 3177 Japanese Men with Androgenetic Alopecia Journal of Dermatology · 2011
    15. Inhibitory Activities of Puerariae Flos Against Testosterone 5α-Reductase and Its Hair Growth Promotion Activities Journal of Natural Medicines · 2011
    16. Molecular Basis of Androgenetic Alopecia: From Androgen to Paracrine Mediators Through Dermal Papilla Journal of Dermatological Science · 2010
    17. Human Hair Growth Enhancement In Vitro By Green Tea Epigallocatechin-3-Gallate (EGCG) Phytomedicine · 2006
    18. Minoxidil: Mechanisms of Action on Hair Growth British Journal of Dermatology · 2004
    19. The Hair Growth Promoting Effect of Sophora Flavescens Extract and Its Molecular Regulation Journal of Dermatological Science · 2002
    20. The Failure Behavior of the Anchorage of Hairs During Slow Extraction Journal of biomechanics · 2001
    21. Androgenetic Alopecia and Microinflammation International Journal of Dermatology · 2000
    22. The Biology of Hair Follicles The New England Journal of Medicine · 1999
    23. Finasteride Drugs · 1999
    24. Finasteride in the Treatment of Men with Androgenetic Alopecia Journal of The American Academy of Dermatology · 1998
    25. Androgen Metabolism as It Affects Hair Growth in Androgenetic Alopecia Dermatologic Clinics · 1996
    26. Effect of Leaves of Ginkgo Biloba on Hair Regrowth in C3H Strain Mice Yakugaku zasshi · 1993
    27. The Metabolism of Dehydroepiandrosterone by Human Scalp Hair Follicles The Journal of Clinical Endocrinology & Metabolism · 1973
    28. Metabolism of Androgens by Isolated Human Hair Follicles Journal of Steroid Biochemistry · 1972