The Gut-Microbiota-Brain Axis: Focus on Gut Steroids

    November 2024 in “ Journal of Neuroendocrinology ”
    Silvia Diviccaro, Silvia Giatti, Lucia Cioffi … Roberto Cosimo Melcangi
    Studysummary This review discusses the role of gut steroids in communicating with the gut microbiota and their potential implications in treating gastrointestinal disorders and related brain conditions, suggesting new perspectives on steroid molecules as therapeutic agents.
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    Research cited in this study 10

    1. Post-Finasteride Syndrome and Post-SSRI Sexual Dysfunction: Two Clinically Similar Conditions Frontiers in Neuroendocrinology · 2023
    2. Pregnenolone for the Treatment of L-DOPA-Induced Dyskinesia in Parkinson's Disease Experimental neurology · 2023
    3. Gut Inflammation Induced by Finasteride Withdrawal: Therapeutic Effect of Allopregnanolone in Adult Male Rats Biomolecules · 2022
    4. Exploring the Impact of the Microbiome on Neuroactive Steroid Levels in Germ-Free Animals International journal of molecular sciences · 2021
    5. Alterations of Gut Microbiota Composition in Post-Finasteride Patients: A Pilot Study Journal of Endocrinological Investigation · 2020
    6. Post-Finasteride Syndrome: An Emerging Clinical Problem Neurobiology of Stress · 2019
    7. Treatment of Male Rats with Finasteride, an Inhibitor of 5alpha-Reductase Enzyme, Induces Long-Lasting Effects on Depressive-Like Behavior, Hippocampal Neurogenesis, Neuroinflammation, and Gut Microbiota Composition Psychoneuroendocrinology · 2018
    8. Neuroactive Steroid Levels and Psychiatric and Andrological Features in Post-Finasteride Patients The Journal of Steroid Biochemistry and Molecular Biology · 2017
    9. Effects of Subchronic Finasteride Treatment and Withdrawal on Neuroactive Steroid Levels and Their Receptors in the Male Rat Brain Neuroendocrinology · 2015
    10. Human Skin Is a Steroidogenic Tissue: Steroidogenic Enzymes and Cofactors Are Expressed in Epidermis, Normal Sebocytes, and an Immortalized Sebocyte Cell Line (SEB-1) Journal of Investigative Dermatology · 2003