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This review examines the promising role of nanocarriers, specifically liposomes and ethosomes, in enhancing transdermal drug delivery for skin diseases. Ethosomes, highlighted for their ability to penetrate deeper skin layers, show potential for more effective treatments but require further clinical investigation.

In this review, biomaterial-based mechanical strategies were highlighted for their potential to enhance skin regeneration and promote scarless repair, though a comprehensive understanding of their underlying mechanisms is still needed for broader application.

The researchers suggest that combining microneedle technology with nanocarriers could enhance drug delivery systems for treating central neurological diseases due to nanoparticles' ability to prolong blood circulation time and improve brain targeting.

This review discusses various nanotechnology-based strategies for managing melasma and reports no new clinical results, highlighting the potential of innovative drug delivery systems in treating hyperpigmentation.

This review discusses the use of terpenes and invasomes as permeation enhancers for transdermal drug delivery, focusing on their potential applications in pharmaceutical formulations, but it reports no new experimental results.

This article outlines how nanotechnology strategies, including phospholipid-based nanocarriers like liposomes, could enhance the effectiveness and skin tolerability of acne treatments, aiming to reduce side effects and improve patient compliance in managing acne vulgaris.

This paper reviews the advancements and applications of single-cell transcriptomics in animal research, highlighting its potential to enhance understanding of animal nutrition, health, genetics, and disease models.

This study found that Brigatinib-loaded nanospanlastics demonstrated enhanced cytotoxicity against lung cancer cells and improved drug stability and release compared to free Brigatinib.

The researchers reported that their novel formulation of pterostilbene-loaded ethoniosomes with folic acid coating effectively targeted lung cancer cells in vitro and demonstrated promising results in animal models, indicating potential for future targeted chemotherapy applications.

This review explores how nanoparticles enhance cosmeceutical formulations, analyzing their roles in transporting active ingredients, and highlights the progress and challenges in using nanotechnology for beauty and health products.

This study found that azelaic acid entrapped in transethosomes exhibited enhanced antidermatophyte activity and improved treatment outcomes in guinea pig models of dermatophytosis compared to free azelaic acid.

This review discusses the progress in research on topical formulations for treating alopecia, highlighting potential advantages of advanced formulation technologies but reporting no new clinical results.

This review provides an overview of caffeine's effects on cancer, cardiovascular, immunological, inflammatory, and neurological diseases, highlighting both its potential benefits, such as neuroprotection and anti-aging, and possible adverse effects like elevated blood pressure, anemia, and migraine.

This review discusses the potential of strontium-containing electrospun nanofibers for bone tissue engineering, outlining their effects on various cell types and highlighting current research challenges and future perspectives in the field.

This study found that using spanlastics, a nano, surfactant-based drug delivery system, improved the bioavailability, drug release characteristics, and pharmacokinetic behavior of famotidine, a poorly soluble drug, by enhancing its dissolution and membrane permeation.

This study found that an intranasal gel containing risperidone-loaded glycethosomes significantly enhanced drug bioavailability and improved neuroprotective, antioxidant, and anti-inflammatory effects in schizophrenia-induced rats compared to oral therapies, suggesting a promising alternative for schizophrenic patients who struggle with adhering to oral medication.

This review highlights the potential of nano-phytopharmaceuticals in improving the bioavailability and efficacy of phytochemicals for treating locomotor, dermal, reproductive, and urinary tract disorders, but notes that more clinical and preclinical research is needed to establish their safety and efficacy for human use.

This review reports on recent surfactant-based niosome formulations, including those with polysaccharides, for versatile drug delivery applications such as ocular, oral, and transdermal settings, while discussing their limitations and potential prospects.

This study developed cilostazol-loaded formulations for nose-to-brain delivery, finding that these formulations improved cilostazol's bioavailability by enhancing solubility, absorption, and permeability, achieving nearly 100% drug release in vitro within 2 hours.

This review examines advancements in lipid and inorganic nanocarriers, such as liposomes and inorganic nanoparticles, for transdermal drug delivery, noting enhanced absorption and stability but acknowledging that few have reached clinical use.

This commentary reviews the application of pharmaceutical nanotechnology in Egypt, highlighting promising developments and diverse drug-delivery approaches, but reports no new research findings.

This review highlights the challenges in developing nano-scale drug delivery systems for natural antioxidants in wound healing, pointing out issues like low solubility and skin permeability, and discusses potential solutions such as combining polymers and lipids to enhance delivery effectiveness.

This review explores the different types of hydrogels used to repair diabetic ulcers, the mechanisms involved, and the limitations in developing these technologies for clinical use, but it reports no new clinical results.

This review paper highlights the development and application of organic and biogenic nanocarriers for delivering bioactives, focusing on eco-friendly and sustainable nanotechnology strategies while addressing challenges like toxicity and paving the way for future innovations in green solution approaches.

This review highlights recent advances in the design of nanocarrier systems for transdermal drug delivery, detailing their potential to improve treatment precision for dermatologic conditions despite challenges like formulation stability and scalability.

This study found that spanlastic gel loaded with thymoquinone and ascorbic acid improved skin deposition and tyrosinase inhibition, suggesting potential as a treatment for hyperpigmentation.

Repaglinide-loaded liponiosomal hybrids improve blood sugar control and insulin release better than regular Repaglinide.

This study reported that encapsulating minoxidil in transferosomes and transethosomes can enhance skin permeability and drug retention compared to its conventional formulation, potentially increasing efficacy in androgenic alopecia treatment while reducing side effects, especially when transethosomes contain oleic acid.

This review examines new formulations for delivering 5-α-reductase inhibitors to improve targeted drug delivery in androgenetic alopecia, but reports no new clinical results.

This paper reviews the development of transdermal drug delivery systems for skin diseases, from first to fourth generation, and highlights ongoing challenges and the importance of clinical trials, but provides no new clinical results.