15 citations
,
March 2014 in “Molecular Medicine Reports” This study found that α-spinasterol treatment significantly reduced testosterone propionate-induced prostatic hyperplasia in rats, suggesting potential benefits for managing benign prostatic hyperplasia.
4 citations
,
December 2013 in “Archivio italiano di urologia, andrologia” This study found that dutasteride may reduce the likelihood of hospitalization for BPH-related surgery and newly detected prostate cancer, compared to finasteride, and suggests a budgetary benefit.
3 citations
,
July 2018 in “African Journal of Urology” This study found that six weeks of finasteride therapy before TURP reduced intraoperative blood loss and improved early postoperative quality of life in patients with benign prostatic hyperplasia.
1 citations
,
April 2019 in “Clinical Breast Cancer” This study found that in men with benign prostatic hyperplasia, 5-alpha reductase inhibitors significantly increased the risk of gynecomastia and breast tenderness compared to placebo or alpha-blockers.
1 citations
,
January 2019 in “PubMed” This study found no correlation between androgenic alopecia and lower urinary tract symptoms or prostate volume in men who underwent a Green Light Laser Vaporization Procedure of the prostate.
1 citations
,
January 2018 in “AUSTRALIAN JOURNAL OF BASIC AND APPLIED SCIENCES” In this study, the ethanol extract of Zapoteca portoricensis stem significantly reduced markers of testosterone-induced benign prostate hyperplasia in male albino rats without harming liver and kidney function.
March 2016 in “National Repository of Dissertations in Serbia” This study found that dutasteride is more cost-effective compared to finasteride for treating benign prostatic hyperplasia in Montenegro, justifying its funding by the national health insurance fund.
301 citations
,
February 2019 in “Nature Communications” In this study, researchers found that wound healing in mouse skin recruits diverse fibroblasts, including myeloid-derived cells, which contribute to regenerating adipocytes.
184 citations
,
October 2007 in “Proceedings of the National Academy of Sciences of the United States of America” This study found that sulforaphane-rich broccoli sprout extracts reduced UV-induced erythema by 37.7% in humans, suggesting a protective strategy against UVR damage.
176 citations
,
August 2015 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology” This study identified a distinct cytokine activation signature in alopecia areata, involving TH2, TH1, IL-23, and IL-9/TH9 pathways, suggesting potential targeting strategies similar to those in psoriasis and atopic dermatitis.
174 citations
,
November 2016 in “Cell stem cell” This study found that squamous cell carcinomas from hair follicle stem cells are more prone to epithelial to mesenchymal transition and metastasis than those from interfollicular epidermis, due to distinct chromatin landscapes.
136 citations
,
February 2017 in “International Journal of Molecular Sciences” This study observed that autologous platelet-rich plasma treatment improved hair count and density in areas with androgenetic alopecia compared to placebo, with differing outcomes based on the PRP collection device used.
124 citations
,
June 2020 in “Cell Stem Cell” This study found that in mice, dermal adipocytes initiate inflammation and aid repair after skin injury by releasing lipids, suggesting a role in managing inflammatory diseases and impaired wound healing.
106 citations
,
June 2005 in “Journal of Investigative Dermatology” This study defines classification criteria for hair follicle dystrophy using a mouse model of chemotherapy-induced alopecia, providing tools for standardized hair damage assessment.
87 citations
,
September 2019 in “Nature Communications” In this study, researchers identified that upon tissue injury in a mouse model, epidermal cells at the wound edge convert to an embryonic-like state with SOX11 and SOX4 playing a central role in modulating epidermal development and cell migration genes.
65 citations
,
October 2018 in “Frontiers in cellular and infection microbiology” This study observed that dandruff in Indian women is associated with a distinct scalp microbiome, including specific bacterial and unknown Malassezia species, with implications for nutrient homeostasis and cell-host adhesion pathways.
64 citations
,
June 2020 in “PLoS ONE” This study found that red light exposure significantly enhanced the growth, phytochemical content, and therapeutic potential of Eclipta alba callus cultures compared to other multispectral light exposures.
61 citations
,
May 2016 in “Scientific reports” This study found that IMT-P8, a novel cell-penetrating peptide, effectively facilitated the dermal delivery of proteins and peptides in mouse skin and cell lines, suggesting potential for topical applications in cosmetics and skin diseases.
57 citations
,
January 1995 in “The American journal of medicine” This study discusses the use of oral contraceptives as a treatment for hyperandrogenism, showing improvement in hirsutism and acne for many women and possibly providing metabolic benefits with certain formulations.
54 citations
,
May 2018 in “Journal of The European Academy of Dermatology and Venereology” This study found that low-level laser therapy was the most effective non-surgical treatment for androgenetic alopecia, although the overall quality of evidence supporting various therapies was generally low.
50 citations
,
July 2021 in “Nature Communications” This study found that the antiandrogen drug enzalutamide reduced TMPRSS2 levels and significantly decreased SARS-CoV-2 entry and infection in lung cells, supporting further clinical trials for COVID-19 treatment.
44 citations
,
August 2017 in “Food Bioscience” This study found that betasitosterol-loaded nanostructured lipid carriers, when added to butter, improved its nutritional profile and antioxidant properties, maintaining stability over a three-month storage period.
44 citations
,
March 2016 in “Frontiers in cellular neuroscience” In this study using zebrafish, four bisbenzylisoquinoline derivatives were found to protect hair cells from aminoglycoside-induced damage without reducing antibiotic efficacy, potentially leading to therapies for patients undergoing such treatments.
41 citations
,
October 2024 in “Nature Communications” In this study, researchers developed a wearable red and blue LED patch and a sprayable fibrin gel to treat infected wounds at home, demonstrating effective infection control and enhanced wound healing in diabetic mice and minipigs.
34 citations
,
March 2011 in “Plastic and Reconstructive Surgery” This study found that custom alloplastic implants achieved a 95% success rate in reconstructing large cranial defects from warfare-related injuries, but frontal defects near airways and orbits showed higher infection and implant removal rates.
33 citations
,
December 2023 in “Cell Death Discovery” This study found that cepharanthine can inhibit gastric cancer cell activity by inducing oxidative stress and altering energy metabolism, suggesting its potential for gastric cancer treatment.
32 citations
,
March 2014 in “PLOS ONE” This study demonstrates that FMOD deficiency in mice alters TGF-β ligand and receptor expression during wound healing stages, leading to delayed wound closure and increased scar size.
31 citations
,
April 2018 in “Royal Society open science” This study found that mange-infected bare-nosed wombats have increased heat loss, higher metabolic rates, altered behavior, and disrupted fatty acid composition compared to healthy individuals.
27 citations
,
September 2018 in “Medicines” This study reported that oleic acid-based nanovesicles improve follicular delivery and reduce side effects of minoxidil compared to traditional MXD lotions.
25 citations
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August 2015 in “Journal of cosmetic dermatology” This study observed significant differences in hair care practices and biologic hair parameters between Caucasian and African American women, which may contribute to varying hair fragility and growth.