Alpha-Spinasterol from Melandrium Firmum Attenuates Benign Prostatic Hyperplasia in a Rat Model
March 2014
in “
Molecular Medicine Reports
”
Studysummary This study found that α-spinasterol treatment significantly reduced testosterone propionate-induced prostatic hyperplasia in rats, suggesting potential benefits for managing benign prostatic hyperplasia.
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The study investigated the effects of α-spinasterol from Melandrium firmum on benign prostatic hyperplasia (BPH) in a rat model. Male Wistar rats were divided into four groups of eight, with treatments administered orally before testosterone propionate (TP) injections. Results showed that TP significantly increased prostate size and levels of testosterone and dihydrotestosterone (DHT). However, α-spinasterol treatment significantly inhibited these increases and suppressed TP-induced prostatic hyperplasia, suggesting that α-spinasterol could be beneficial in managing BPH.
